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• W2092247994 abstract "Human gene association studies have produced conflicting findings regarding the relationship between the 5-HT transporter (5-HTT) and anxiety. In the present study genetically modified mice were utilised to examine the effects of changes in 5-HTT expression on anxiety. In addition, the influence of 5-HTT expression on two innate “species-typical” behaviours (burrowing and marble burying) and body weight was explored. Across a range of models, 5-HTT overexpressing mice displayed reduced anxiety-like behaviour whilst 5-HTT knockout mice showed increased anxiety-like behaviour, compared to wildtype controls. In tests of species-typical behaviour 5-HTT overexpressing mice showed some facilitation whilst 5-HTT knockout mice were impaired. Reciprocal effects were also seen on body weight, as 5-HTT overexpressors were lighter and 5-HTT knockouts were heavier than wildtype controls. These findings show that variation in 5-HTT gene expression produces robust changes in anxiety and species-typical behaviour. Furthermore, the data add further support to findings that variation of 5-HTT expression in the human population is linked to changes in anxiety-related personality traits." @default.
• W2092247994 created "2016-06-24" @default.
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• W2092247994 date "2011-01-01" @default.
• W2092247994 modified "2023-10-11" @default.
• W2092247994 title "Opposing alterations in anxiety and species-typical behaviours in serotonin transporter overexpressor and knockout mice" @default.
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• W2092247994 doi "https://doi.org/10.1016/j.euroneuro.2010.08.005" @default.
• W2092247994 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3038260" @default.
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