FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092248825> ?p ?o ?g. }

• W2092248825 endingPage "845" @default.
• W2092248825 startingPage "845" @default.
• W2092248825 abstract "Artesunate, a derivative of artemisinin isolated from Artemisia annua L., has been traditionally used to treat malaria, and artesunate has demonstrated cytotoxic effects against a variety of cancer cells. However, there is little available information about the antitumor effects of artesunate on human gastric cancer cells. In the present study, we investigated the antitumor effect of artesunate on human gastric cancer cells and whether its antitumor effect is associated with reduction in COX-2 expression. The effects of artesunate on the growth and apoptosis of gastric cancer cells were investigated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, flow cytometric analysis of annexin V-fluorescein isothiocyanate/propidium iodide staining, rhodamine 123 staining, and Western blot analysis. Results indicate that artesunate exhibits antiproliferative effects and apoptosis-inducing activities. Artesunate markedly inhibited gastric cancer cell proliferation in a time- and dose-dependent manner and induced apoptosis in gastric cancer cells a dose-dependent manner, which was associated with a reduction in COX-2 expression. Treatment with the selective COX-2 inhibitor celecoxib, or transient transfection of gastric cancer cells with COX-2 siRNA, also inhibited cell proliferation and induced apoptosis. Furthermore, the treatment with artesunate promoted the expression of proapoptotic factor Bax and suppressed the expression of antiapoptotic factor Bcl-2. In addition, caspase-3 and caspase-9 were activated, and artesunate induced loss of mitochondrial membrane potential, suggesting that the apoptosis is mediated by mitochondrial pathways. These results demonstrate that artesunate has an effect on anti-gastric cancer cells. One of the antitumor mechanisms of artesunate may be that its inhibition of COX-2 led to reduced proliferation and induction of apoptosis, connected with mitochondrial dysfunction. Artesunate might be a potential therapeutic agent for gastric cancer." @default.
• W2092248825 created "2016-06-24" @default.
• W2092248825 creator A5021384155 @default.
• W2092248825 creator A5024577852 @default.
• W2092248825 creator A5055151897 @default.
• W2092248825 creator A5063797577 @default.
• W2092248825 date "2015-04-01" @default.
• W2092248825 modified "2023-10-17" @default.
• W2092248825 title "Artesunate inhibits the growth and induces apoptosis of human gastric cancer cells by&nbsp;downregulating COX-2" @default.
• W2092248825 cites W1576201010 @default.
• W2092248825 cites W1800050944 @default.
• W2092248825 cites W1966473790 @default.
• W2092248825 cites W1978503888 @default.
• W2092248825 cites W2003154269 @default.
• W2092248825 cites W2010899039 @default.
• W2092248825 cites W2011817759 @default.
• W2092248825 cites W2024273207 @default.
• W2092248825 cites W2026496537 @default.
• W2092248825 cites W2031203591 @default.
• W2092248825 cites W2033992955 @default.
• W2092248825 cites W2035228001 @default.
• W2092248825 cites W2041026552 @default.
• W2092248825 cites W2052827925 @default.
• W2092248825 cites W2056320217 @default.
• W2092248825 cites W2059722530 @default.
• W2092248825 cites W2060001014 @default.
• W2092248825 cites W2062051365 @default.
• W2092248825 cites W2063812739 @default.
• W2092248825 cites W2066634650 @default.
• W2092248825 cites W2074738823 @default.
• W2092248825 cites W2075376891 @default.
• W2092248825 cites W2087744847 @default.
• W2092248825 cites W2088475360 @default.
• W2092248825 cites W2095000156 @default.
• W2092248825 cites W2098803781 @default.
• W2092248825 cites W2113741061 @default.
• W2092248825 cites W2113947048 @default.
• W2092248825 cites W2116304851 @default.
• W2092248825 cites W2124307160 @default.
• W2092248825 cites W2132069490 @default.
• W2092248825 cites W2148122132 @default.
• W2092248825 cites W2149233326 @default.
• W2092248825 cites W2156470937 @default.
• W2092248825 cites W2161483205 @default.
• W2092248825 cites W2161817637 @default.
• W2092248825 cites W2169404907 @default.
• W2092248825 cites W2169590959 @default.
• W2092248825 cites W2170753182 @default.
• W2092248825 doi "https://doi.org/10.2147/ott.s81041" @default.
• W2092248825 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4406257" @default.
• W2092248825 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25945055" @default.
• W2092248825 hasPublicationYear "2015" @default.
• W2092248825 type Work @default.
• W2092248825 sameAs 2092248825 @default.
• W2092248825 citedByCount "45" @default.
• W2092248825 countsByYear W20922488252015 @default.
• W2092248825 countsByYear W20922488252016 @default.
• W2092248825 countsByYear W20922488252017 @default.
• W2092248825 countsByYear W20922488252018 @default.
• W2092248825 countsByYear W20922488252019 @default.
• W2092248825 countsByYear W20922488252020 @default.
• W2092248825 countsByYear W20922488252021 @default.
• W2092248825 countsByYear W20922488252022 @default.
• W2092248825 countsByYear W20922488252023 @default.
• W2092248825 crossrefType "journal-article" @default.
• W2092248825 hasAuthorship W2092248825A5021384155 @default.
• W2092248825 hasAuthorship W2092248825A5024577852 @default.
• W2092248825 hasAuthorship W2092248825A5055151897 @default.
• W2092248825 hasAuthorship W2092248825A5063797577 @default.
• W2092248825 hasBestOaLocation W20922488251 @default.
• W2092248825 hasConcept C121608353 @default.
• W2092248825 hasConcept C126322002 @default.
• W2092248825 hasConcept C185592680 @default.
• W2092248825 hasConcept C190283241 @default.
• W2092248825 hasConcept C203014093 @default.
• W2092248825 hasConcept C2775934118 @default.
• W2092248825 hasConcept C2778048844 @default.
• W2092248825 hasConcept C2778059366 @default.
• W2092248825 hasConcept C2778371730 @default.
• W2092248825 hasConcept C31573885 @default.
• W2092248825 hasConcept C502942594 @default.
• W2092248825 hasConcept C55493867 @default.
• W2092248825 hasConcept C71924100 @default.
• W2092248825 hasConcept C86803240 @default.
• W2092248825 hasConcept C88634738 @default.
• W2092248825 hasConcept C96232424 @default.
• W2092248825 hasConcept C98274493 @default.
• W2092248825 hasConceptScore W2092248825C121608353 @default.
• W2092248825 hasConceptScore W2092248825C126322002 @default.
• W2092248825 hasConceptScore W2092248825C185592680 @default.
• W2092248825 hasConceptScore W2092248825C190283241 @default.
• W2092248825 hasConceptScore W2092248825C203014093 @default.
• W2092248825 hasConceptScore W2092248825C2775934118 @default.
• W2092248825 hasConceptScore W2092248825C2778048844 @default.
• W2092248825 hasConceptScore W2092248825C2778059366 @default.
• W2092248825 hasConceptScore W2092248825C2778371730 @default.
• W2092248825 hasConceptScore W2092248825C31573885 @default.
• W2092248825 hasConceptScore W2092248825C502942594 @default.

• next