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- W2092251272 abstract "Background: The role of acid secretion in reflux oesophagitis which may develop after H. pylori eradication is not well known. Aim: To investigate the participation of altered gastric acid secretion and the presence of hiatal hernia in the development of reflux oesophagitis after eradication therapy for H. pylori . Subjects and Methods: A total of 105 patients with H. pylori infection, but without reflux oesophagitis at the time of eradication therapy, were followed prospectively for 7 months after the clearance of this microorganism. Gastric acid secretion was assessed by endoscopic gastrin test, and the presence of hiatal hernia by endoscopy. Results: Reflux oesophagitis developed in 11 out of 105 (10.5%) patients when examined at 7 months after the eradication therapy. The incidence was correlated significantly with the increase in gastric acid secretion after the eradication of H. pylori , and was significantly higher in the patients with hiatal hernia (20%) than in those without it (0%). Conclusions: Increased acid secretion after H. pylori eradication is an important risk factor of reflux oesophagitis, especially in patients with hiatal hernia." @default.
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- W2092251272 date "2001-06-12" @default.
- W2092251272 modified "2023-10-18" @default.
- W2092251272 title "Increased gastric acid secretion after <i>Helicobacter pylori</i> eradication may be a factor for developing reflux oesophagitis" @default.
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- W2092251272 doi "https://doi.org/10.1046/j.1365-2036.2001.00988.x" @default.
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