FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092255525> ?p ?o ?g. }

• W2092255525 endingPage "2215" @default.
• W2092255525 startingPage "2205" @default.
• W2092255525 abstract "Toxin-antitoxin (TA) systems form a ubiquitous class of prokaryotic proteins with functional roles in plasmid inheritance, environmental stress response, and cell development. ParDE family TA systems are broadly conserved on plasmids and bacterial chromosomes and have been well characterized as genetic elements that promote stable plasmid inheritance. We present a crystal structure of a chromosomally encoded ParD-ParE complex from Caulobacter crescentus at 2.6 A resolution. This TA system forms an alpha(2)beta(2) heterotetramer in the crystal and in solution. The toxin-antitoxin binding interface reveals extensive polar and hydrophobic contacts of ParD antitoxin helices with a conserved recognition and binding groove on the ParE toxin. A cross-species comparison of this complex structure with related toxin structures identified an antitoxin recognition and binding subdomain that is conserved between distantly related members of the RelE/ParE toxin superfamily despite a low level of overall primary sequence identity. We further demonstrate that ParD antitoxin is dimeric, stably folded, and largely helical when not bound to ParE toxin. Thus, the paradigmatic model in which antitoxin undergoes a disorder-to-order transition upon toxin binding does not apply to this chromosomal ParD-ParE TA system." @default.
• W2092255525 created "2016-06-24" @default.
• W2092255525 creator A5027452507 @default.
• W2092255525 creator A5068647102 @default.
• W2092255525 date "2010-02-17" @default.
• W2092255525 modified "2023-10-16" @default.
• W2092255525 title "A Conserved Mode of Protein Recognition and Binding in a ParD−ParE Toxin−Antitoxin Complex" @default.
• W2092255525 cites W1508202631 @default.
• W2092255525 cites W1518977299 @default.
• W2092255525 cites W1559209718 @default.
• W2092255525 cites W1584174944 @default.
• W2092255525 cites W1604915411 @default.
• W2092255525 cites W1725358412 @default.
• W2092255525 cites W1914760274 @default.
• W2092255525 cites W1936065549 @default.
• W2092255525 cites W1964580946 @default.
• W2092255525 cites W1973010341 @default.
• W2092255525 cites W1975085160 @default.
• W2092255525 cites W1975317507 @default.
• W2092255525 cites W1976920382 @default.
• W2092255525 cites W1977038370 @default.
• W2092255525 cites W1979509787 @default.
• W2092255525 cites W1989869773 @default.
• W2092255525 cites W1996810865 @default.
• W2092255525 cites W1999923587 @default.
• W2092255525 cites W2005528894 @default.
• W2092255525 cites W2009010596 @default.
• W2092255525 cites W2017530458 @default.
• W2092255525 cites W2021197152 @default.
• W2092255525 cites W2022115313 @default.
• W2092255525 cites W2024468809 @default.
• W2092255525 cites W2024645073 @default.
• W2092255525 cites W2046219181 @default.
• W2092255525 cites W2054572399 @default.
• W2092255525 cites W2066088601 @default.
• W2092255525 cites W2070252217 @default.
• W2092255525 cites W2075518131 @default.
• W2092255525 cites W2079718040 @default.
• W2092255525 cites W2081541337 @default.
• W2092255525 cites W2091452994 @default.
• W2092255525 cites W2093264253 @default.
• W2092255525 cites W2093814623 @default.
• W2092255525 cites W2095014009 @default.
• W2092255525 cites W2105753010 @default.
• W2092255525 cites W2107986672 @default.
• W2092255525 cites W2126573196 @default.
• W2092255525 cites W2136833370 @default.
• W2092255525 cites W2137955461 @default.
• W2092255525 cites W2141365940 @default.
• W2092255525 cites W2147531848 @default.
• W2092255525 cites W2153148799 @default.
• W2092255525 cites W2157378009 @default.
• W2092255525 cites W2158992333 @default.
• W2092255525 cites W2163341755 @default.
• W2092255525 cites W2167639479 @default.
• W2092255525 cites W2412579716 @default.
• W2092255525 cites W4242821027 @default.
• W2092255525 cites W4244736178 @default.
• W2092255525 doi "https://doi.org/10.1021/bi902133s" @default.
• W2092255525 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2846751" @default.
• W2092255525 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20143871" @default.
• W2092255525 hasPublicationYear "2010" @default.
• W2092255525 type Work @default.
• W2092255525 sameAs 2092255525 @default.
• W2092255525 citedByCount "70" @default.
• W2092255525 countsByYear W20922555252012 @default.
• W2092255525 countsByYear W20922555252013 @default.
• W2092255525 countsByYear W20922555252014 @default.
• W2092255525 countsByYear W20922555252015 @default.
• W2092255525 countsByYear W20922555252016 @default.
• W2092255525 countsByYear W20922555252017 @default.
• W2092255525 countsByYear W20922555252018 @default.
• W2092255525 countsByYear W20922555252019 @default.
• W2092255525 countsByYear W20922555252020 @default.
• W2092255525 countsByYear W20922555252021 @default.
• W2092255525 countsByYear W20922555252022 @default.
• W2092255525 countsByYear W20922555252023 @default.
• W2092255525 crossrefType "journal-article" @default.
• W2092255525 hasAuthorship W2092255525A5027452507 @default.
• W2092255525 hasAuthorship W2092255525A5068647102 @default.
• W2092255525 hasBestOaLocation W20922555252 @default.
• W2092255525 hasConcept C104317684 @default.
• W2092255525 hasConcept C167625842 @default.
• W2092255525 hasConcept C199216141 @default.
• W2092255525 hasConcept C22744801 @default.
• W2092255525 hasConcept C2777367657 @default.
• W2092255525 hasConcept C2778973234 @default.
• W2092255525 hasConcept C54355233 @default.
• W2092255525 hasConcept C86803240 @default.
• W2092255525 hasConcept C89423630 @default.
• W2092255525 hasConceptScore W2092255525C104317684 @default.
• W2092255525 hasConceptScore W2092255525C167625842 @default.
• W2092255525 hasConceptScore W2092255525C199216141 @default.
• W2092255525 hasConceptScore W2092255525C22744801 @default.
• W2092255525 hasConceptScore W2092255525C2777367657 @default.
• W2092255525 hasConceptScore W2092255525C2778973234 @default.
• W2092255525 hasConceptScore W2092255525C54355233 @default.
• W2092255525 hasConceptScore W2092255525C86803240 @default.

• next