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- W2092262479 abstract "The shal gene encodes the transient potassium current (I(A)) in neurons of the lobster stomatogastric ganglion. Overexpression of Shal by RNA injection into neurons produces a large increase in I(A), but surprisingly little change in the neuron's firing properties. Accompanying the increase in I(A) is a dramatic and linearly correlated increase in the hyperpolarization-activated inward current (I(h)). The enhanced I(h) electrophysiologically compensates for the enhanced I(A), since pharmacological blockade of I(h) uncovers the physiological effects of the increased I(A). Expression of a nonfunctional mutant Shal also induces a large increase in I(h), demonstrating a novel activity-independent coupling between the Shal protein and I(h) enhancement. Since I(A) and I(h) influence neuronal activity in opposite directions, our results suggest a selective coregulation of these channels as a mechanism for constraining cell activity within appropriate physiological parameters." @default.
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- W2092262479 date "2003-01-01" @default.
- W2092262479 modified "2023-09-24" @default.
- W2092262479 title "Activity-Independent Homeostasis in Rhythmically Active Neurons" @default.
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- W2092262479 doi "https://doi.org/10.1016/s0896-6273(02)01104-2" @default.
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