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- W2092280672 abstract "Venezuelan equine encephalitis virus replicon particles (VRP) were engineered to express different forms of SIV Gag to compare expression in vitro , formation of intra- and extracellular structures and induction of humoral and cellular immunity in mice. The three forms examined were full-length myristylated SIV Gag (Gag myr+ ), full-length Gag lacking the myristylation signal (Gag myr− ) or a truncated form of Gag myr− comprising only the matrix and capsid domains (MA/CA). Comparison of VRP-infected primary mouse embryo fibroblasts, mouse L929 cells and primate Vero cells showed comparable expression levels for each protein, as well as extracellular virus-like particles (VRP-Gag myr+ ) and distinctive cytoplasmic aggregates (VRP-Gag myr− ) with each cell type. VRP were used to immunize BALB/c mice, and immune responses were compared using an interferon (IFN)-γ ELISPOT assay and a serum antibody ELISA. Although all three VRP generated similar levels of IFN-γ-producing cells at 1 week post-boost, at 10 weeks post-boost the MA/CA-VRP-induced response was maintained at a significantly higher level relative to that induced by Gag myr+ -VRP. Antibody responses to MA/CA-VRP and Gag myr+ -VRP were not significantly different." @default.
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- W2092280672 date "2007-06-01" @default.
- W2092280672 modified "2023-09-27" @default.
- W2092280672 title "Structure and immunogenicity of alternative forms of the simian immunodeficiency virus gag protein expressed using Venezuelan equine encephalitis virus replicon particles" @default.
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- W2092280672 doi "https://doi.org/10.1016/j.virol.2006.12.029" @default.
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