FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092287941> ?p ?o ?g. }

• W2092287941 endingPage "6170" @default.
• W2092287941 startingPage "6164" @default.
• W2092287941 abstract "Escherichia coli endonuclease III and mammalian repair enzymes cleave UV-irradiated DNA at AP sites formed by the removal of cytosine photoproducts by the DNA glycosylase activity of these enzymes. Poly(dG-[3H]dC) was UV irradiated and incubated with purified endonuclease III. 3H-Containing material was released in a fashion consistent with Michaelis-Menten kinetics. This 3H material was determined to be cytosine by chromatography in two independent systems and microderivatization. 3H-Containing material was not released from nonirradiated copolymer. When poly(dA-[3H]dU) was UV irradiated, endonuclease III released 3H-containing material that coeluted with uracil hydrate (6-hydroxy-5,6-dihydrouracil). Similar results are obtained by using extracts of HeLa cells. There results indicate that the modified cytosine residue recognized by endonuclease III and the mammalian enzyme is cytosine hydrate (6-hydroxy-5,6-dihydrocytosine). Once released from DNA through DNA-glycosylase action, the compound eliminates water, reverting to cytosine. This is consistent with the known instability of cytosine hydrate. The repairability of cytosine hydrate in DNA suggests that it is stable in DNA and potentially genotoxic." @default.
• W2092287941 created "2016-06-24" @default.
• W2092287941 creator A5031002064 @default.
• W2092287941 creator A5032864746 @default.
• W2092287941 creator A5043842379 @default.
• W2092287941 creator A5063314670 @default.
• W2092287941 creator A5086507003 @default.
• W2092287941 date "1989-07-25" @default.
• W2092287941 modified "2023-10-16" @default.
• W2092287941 title "UV-induced pyrimidine hydrates in DNA are repaired by bacterial and mammalian DNA glycosylase activities" @default.
• W2092287941 cites W1570917001 @default.
• W2092287941 cites W1579004914 @default.
• W2092287941 cites W1948333092 @default.
• W2092287941 cites W1963853572 @default.
• W2092287941 cites W1964484839 @default.
• W2092287941 cites W1968140064 @default.
• W2092287941 cites W1971283428 @default.
• W2092287941 cites W1988230291 @default.
• W2092287941 cites W1995537422 @default.
• W2092287941 cites W2008145405 @default.
• W2092287941 cites W2011634180 @default.
• W2092287941 cites W2034129646 @default.
• W2092287941 cites W2041758132 @default.
• W2092287941 cites W2045712590 @default.
• W2092287941 cites W2054551897 @default.
• W2092287941 cites W2059693060 @default.
• W2092287941 cites W206832332 @default.
• W2092287941 cites W2075236139 @default.
• W2092287941 cites W2088031757 @default.
• W2092287941 cites W2088683419 @default.
• W2092287941 cites W2121629473 @default.
• W2092287941 cites W2184161959 @default.
• W2092287941 cites W2206749554 @default.
• W2092287941 doi "https://doi.org/10.1021/bi00441a007" @default.
• W2092287941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2675965" @default.
• W2092287941 hasPublicationYear "1989" @default.
• W2092287941 type Work @default.
• W2092287941 sameAs 2092287941 @default.
• W2092287941 citedByCount "107" @default.
• W2092287941 countsByYear W20922879412014 @default.
• W2092287941 countsByYear W20922879412015 @default.
• W2092287941 countsByYear W20922879412016 @default.
• W2092287941 countsByYear W20922879412018 @default.
• W2092287941 countsByYear W20922879412021 @default.
• W2092287941 countsByYear W20922879412023 @default.
• W2092287941 crossrefType "journal-article" @default.
• W2092287941 hasAuthorship W2092287941A5031002064 @default.
• W2092287941 hasAuthorship W2092287941A5032864746 @default.
• W2092287941 hasAuthorship W2092287941A5043842379 @default.
• W2092287941 hasAuthorship W2092287941A5063314670 @default.
• W2092287941 hasAuthorship W2092287941A5086507003 @default.
• W2092287941 hasConcept C134935766 @default.
• W2092287941 hasConcept C145782189 @default.
• W2092287941 hasConcept C153911025 @default.
• W2092287941 hasConcept C167975912 @default.
• W2092287941 hasConcept C181199279 @default.
• W2092287941 hasConcept C185592680 @default.
• W2092287941 hasConcept C192396546 @default.
• W2092287941 hasConcept C2776023528 @default.
• W2092287941 hasConcept C2776858809 @default.
• W2092287941 hasConcept C2778711568 @default.
• W2092287941 hasConcept C2779321679 @default.
• W2092287941 hasConcept C2779554091 @default.
• W2092287941 hasConcept C552990157 @default.
• W2092287941 hasConcept C55493867 @default.
• W2092287941 hasConcept C86803240 @default.
• W2092287941 hasConceptScore W2092287941C134935766 @default.
• W2092287941 hasConceptScore W2092287941C145782189 @default.
• W2092287941 hasConceptScore W2092287941C153911025 @default.
• W2092287941 hasConceptScore W2092287941C167975912 @default.
• W2092287941 hasConceptScore W2092287941C181199279 @default.
• W2092287941 hasConceptScore W2092287941C185592680 @default.
• W2092287941 hasConceptScore W2092287941C192396546 @default.
• W2092287941 hasConceptScore W2092287941C2776023528 @default.
• W2092287941 hasConceptScore W2092287941C2776858809 @default.
• W2092287941 hasConceptScore W2092287941C2778711568 @default.
• W2092287941 hasConceptScore W2092287941C2779321679 @default.
• W2092287941 hasConceptScore W2092287941C2779554091 @default.
• W2092287941 hasConceptScore W2092287941C552990157 @default.
• W2092287941 hasConceptScore W2092287941C55493867 @default.
• W2092287941 hasConceptScore W2092287941C86803240 @default.
• W2092287941 hasIssue "15" @default.
• W2092287941 hasLocation W20922879411 @default.
• W2092287941 hasLocation W20922879412 @default.
• W2092287941 hasOpenAccess W2092287941 @default.
• W2092287941 hasPrimaryLocation W20922879411 @default.
• W2092287941 hasRelatedWork W143460927 @default.
• W2092287941 hasRelatedWork W1817150603 @default.
• W2092287941 hasRelatedWork W1938898050 @default.
• W2092287941 hasRelatedWork W1966297649 @default.
• W2092287941 hasRelatedWork W1968451541 @default.
• W2092287941 hasRelatedWork W2040105955 @default.
• W2092287941 hasRelatedWork W2056986228 @default.
• W2092287941 hasRelatedWork W2072063319 @default.
• W2092287941 hasRelatedWork W2075323777 @default.
• W2092287941 hasRelatedWork W3160357290 @default.
• W2092287941 hasVolume "28" @default.
• W2092287941 isParatext "false" @default.

• next