Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092288116> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2092288116 endingPage "276A" @default.
- W2092288116 startingPage "276A" @default.
- W2092288116 abstract "The mechanism by which viral infection can lead to the multiple metabolic derangements characteristic of Reye's Syndrome is not understood. The possibility that influenza virus could induce changes in membrane permeability to nutrients ordinarily concentrated within the cell was examined. Madin Darbin canine kidney (MDCK) cells were infected by egg grown influenza B virus by two routes: at physiological conditions, pH 7.4, 37°C; and adsorption at 0°C followed by brief exposure to pH 5.0, 37°C. Control cells were mock-infected with allantoic fluid. Transport (uptake and release) of phosphate (Pi) 2-deoxyglucose (dGlc) and α-aminoisobutyric acid (AIB) were measured at various intervals 0 to 10 hours after infection. At physiological pH, Pi uptake by infected cells was inhibited (p< 0.01) at 0 to 2 hours as compared to controls. Uptake of AIB was also inhibited (p< 0.01) at 0 to 2 hours. The uptake of all nutrients was higher at 6 to 10 hours in infected cells as compared to controls (p< 0.01). When release of Pi and dGlc was measured, there was no difference between infected cells and controls at 0-10 hours. At low pH, fusion occurred in infected cells, but not in control cells. Fused infected cells demonstrated both significantly increased release and diminished uptake of nutrients compared to controls. Thus influenza B virus can induce changes in host cell membrane permeability that may have important implications for cell metabolism." @default.
- W2092288116 created "2016-06-24" @default.
- W2092288116 creator A5008979467 @default.
- W2092288116 creator A5046642925 @default.
- W2092288116 creator A5057728149 @default.
- W2092288116 creator A5080510100 @default.
- W2092288116 creator A5086451928 @default.
- W2092288116 date "1984-04-01" @default.
- W2092288116 modified "2023-09-26" @default.
- W2092288116 title "VIRALLY INDUCED MEMBRANE PERMEABILITY CHANGES AS A POSSIBLE LINK BETWEEN INFLUENZA B AND REYE'S SYNDROME" @default.
- W2092288116 doi "https://doi.org/10.1203/00006450-198404001-01099" @default.
- W2092288116 hasPublicationYear "1984" @default.
- W2092288116 type Work @default.
- W2092288116 sameAs 2092288116 @default.
- W2092288116 citedByCount "0" @default.
- W2092288116 crossrefType "journal-article" @default.
- W2092288116 hasAuthorship W2092288116A5008979467 @default.
- W2092288116 hasAuthorship W2092288116A5046642925 @default.
- W2092288116 hasAuthorship W2092288116A5057728149 @default.
- W2092288116 hasAuthorship W2092288116A5080510100 @default.
- W2092288116 hasAuthorship W2092288116A5086451928 @default.
- W2092288116 hasBestOaLocation W20922881161 @default.
- W2092288116 hasConcept C126322002 @default.
- W2092288116 hasConcept C134018914 @default.
- W2092288116 hasConcept C142796444 @default.
- W2092288116 hasConcept C1491633281 @default.
- W2092288116 hasConcept C159047783 @default.
- W2092288116 hasConcept C185592680 @default.
- W2092288116 hasConcept C18903297 @default.
- W2092288116 hasConcept C2522874641 @default.
- W2092288116 hasConcept C2777302536 @default.
- W2092288116 hasConcept C2909133680 @default.
- W2092288116 hasConcept C2992270614 @default.
- W2092288116 hasConcept C2994297994 @default.
- W2092288116 hasConcept C41625074 @default.
- W2092288116 hasConcept C55493867 @default.
- W2092288116 hasConcept C62231903 @default.
- W2092288116 hasConcept C71924100 @default.
- W2092288116 hasConcept C86803240 @default.
- W2092288116 hasConceptScore W2092288116C126322002 @default.
- W2092288116 hasConceptScore W2092288116C134018914 @default.
- W2092288116 hasConceptScore W2092288116C142796444 @default.
- W2092288116 hasConceptScore W2092288116C1491633281 @default.
- W2092288116 hasConceptScore W2092288116C159047783 @default.
- W2092288116 hasConceptScore W2092288116C185592680 @default.
- W2092288116 hasConceptScore W2092288116C18903297 @default.
- W2092288116 hasConceptScore W2092288116C2522874641 @default.
- W2092288116 hasConceptScore W2092288116C2777302536 @default.
- W2092288116 hasConceptScore W2092288116C2909133680 @default.
- W2092288116 hasConceptScore W2092288116C2992270614 @default.
- W2092288116 hasConceptScore W2092288116C2994297994 @default.
- W2092288116 hasConceptScore W2092288116C41625074 @default.
- W2092288116 hasConceptScore W2092288116C55493867 @default.
- W2092288116 hasConceptScore W2092288116C62231903 @default.
- W2092288116 hasConceptScore W2092288116C71924100 @default.
- W2092288116 hasConceptScore W2092288116C86803240 @default.
- W2092288116 hasLocation W20922881161 @default.
- W2092288116 hasOpenAccess W2092288116 @default.
- W2092288116 hasPrimaryLocation W20922881161 @default.
- W2092288116 hasRelatedWork W2031155162 @default.
- W2092288116 hasRelatedWork W2069414163 @default.
- W2092288116 hasRelatedWork W2092288116 @default.
- W2092288116 hasRelatedWork W2158538495 @default.
- W2092288116 hasRelatedWork W2213375523 @default.
- W2092288116 hasRelatedWork W2356919006 @default.
- W2092288116 hasRelatedWork W2391228787 @default.
- W2092288116 hasRelatedWork W4361199454 @default.
- W2092288116 hasRelatedWork W968709639 @default.
- W2092288116 hasRelatedWork W2416850455 @default.
- W2092288116 hasVolume "18" @default.
- W2092288116 isParatext "false" @default.
- W2092288116 isRetracted "false" @default.
- W2092288116 magId "2092288116" @default.
- W2092288116 workType "article" @default.