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• W2092289037 abstract "The gap junction membrane channel is composed of macular aggregations of intercellular channels permitting the direct intercellular transfer of ions and small molecules. Each intercellular channel is formed by the apposition of two hexameric transmembrane channels (connexons), one from each cell. The interlocking of the two channels occurs extracellularly in a narrow 2.5-nm gap separating the junctional membranes. The channel-channel interaction is known to be selective between members of the family of proteins, called connexins, which oligomerize into the connexons. In addition to selectivity, the molecular interfaces involved in the extracellular interactions between connexons must be very congruent, since the intercellular channel must provide high resistances to the leakage of small ions between the channel lumen and the extracellular space. By using a recently developed biochemical procedure for obtaining ordered arrays of connexons from gap junctions split in the extracellular gap, (Ghoshroy, S., D. A. Goodenough, and G. E. Sosinsky. 1994. Preparation, characterization, and structure of half gap junctional layers spit with urea and EGTA. J. Membr. Biol. 146:15-28) a three-dimensional reconstruction of a connexon has been obtained by electron crystallographic methods. This reconstruction emphasizes the structural asymmetry between the extracellular and cytoplasmic domains and assigns lobed structural features to the extracellular domains of the connexon. The implication of our hemichannel structure is discussed in relation to the in vivo state of unpaired connexons, which have been shown to exist in the plasma membrane." @default.
• W2092289037 created "2016-06-24" @default.
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• W2092289037 creator A5033530478 @default.
• W2092289037 creator A5043619697 @default.
• W2092289037 date "1997-02-01" @default.
• W2092289037 modified "2023-10-16" @default.
• W2092289037 title "Three-Dimensional Structure of the Gap Junction Connexon" @default.
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• W2092289037 doi "https://doi.org/10.1016/s0006-3495(97)78693-4" @default.
• W2092289037 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1185582" @default.
• W2092289037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9017184" @default.
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