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• W2092290410 abstract "We examined the regulation/expression of angiotensin II (Ang II) receptors in the transgenic (TG) (mRen-2)27 rat compared to the normal Sprague-Dawley (SD) rat. Ang II receptor binding and mRNA expression were determined by quantitative autoradiography and real-time PCR, respectively. Ang II receptors in the rat prostate rat were of the AT1 receptor subtype and were significantly reduced in the prostate of the TG rat compared to the normal SD rat. However, AT1 receptor binding was significantly higher in the prostate of the TG rat treated with the ACE inhibitor lisinopril compared to the untreated TG rat and comparable to the control SD rat. In contrast to the protein, AT1 receptor mRNA expression was not reduced in the prostate of the TG rat compared to the SD rat. However, AT1 receptor mRNA was markedly reduced in the prostate of the lisinopril-treated TG rat compared to the untreated TG rat or control SD rat. In conclusion, the findings suggest that AT1 receptors are present in the rat prostate at a protein level and are subject to down-regulation in the TG rat which may be due to receptor internalisation as a consequence of receptor hyper-stimulation by increased local tissue levels of Ang II. Moreover, AT1 receptor protein and mRNA expression in the prostate may be inversely modulated." @default.
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• W2092290410 date "2003-06-01" @default.
• W2092290410 modified "2023-09-25" @default.
• W2092290410 title "Regulation of angiotensin II receptors in the prostate of the transgenic (mRen-2)27 rat: effect of angiotensin-converting enzyme inhibition" @default.
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• W2092290410 doi "https://doi.org/10.1016/s1357-2725(02)00303-5" @default.
• W2092290410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12676181" @default.
• W2092290410 hasPublicationYear "2003" @default.
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