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• W2092302260 endingPage "159" @default.
• W2092302260 startingPage "148" @default.
• W2092302260 abstract "Matrix metalloproteinases (MMPs) are enzymes with specificity towards extracellular matrix (ECM) components. MMPs, especially MMP-9, have been shown to degrade components of the basal lamina and disrupt the blood-brain barrier (BBB) and thus, contribute to neuroinflammation. In the present study we examined the role of MMP-9 in the foreign body response in the brain. Millipore filters of mixed cellulose ester were implanted into the brain cortex of wild type and MMP-9-null mice for a period of 2 d to 8 wks and the response was analyzed by histology and immunohistochemistry. We observed enhanced and prolonged neuroinflammation in MMP-9-null mice, evidenced by persistence of neutrophils, macrophages/microglia, and reactive astrocytes up to 8 wks post-implantation. In addition, blood vessel density around implants was increased in MMP-9-null mice and detection of mouse serum albumin (MSA) indicated that vessels were leaky. Immunohistochemical and western blot analyses indicated that this defect was associated with the absence of tight junction proteins zonula occludens-1 (ZO-1) and ZO-2 from vessels in proximity to implants. Analysis of brain sections and brain protein extracts revealed that the levels of the pro-inflammatory cytokine interleukin-1beta (IL-1beta), which is a substrate for MMP-9, were significantly higher in MMP-9-null mice at 8wks post-implantation. Collectively, our studies suggest that increased levels of IL-1beta and the delayed repair of BBB are associated with prolongation of the FBR in MMP-9-null mice." @default.
• W2092302260 created "2016-06-24" @default.
• W2092302260 creator A5019694310 @default.
• W2092302260 creator A5030554560 @default.
• W2092302260 date "2009-04-01" @default.
• W2092302260 modified "2023-10-16" @default.
• W2092302260 title "Matrix metalloproteinase-9 deficiency leads to prolonged foreign body response in the brain associated with increased IL-1β levels and leakage of the blood-brain barrier" @default.
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• W2092302260 doi "https://doi.org/10.1016/j.matbio.2009.02.002" @default.
• W2092302260 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3624973" @default.
• W2092302260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19264129" @default.
• W2092302260 hasPublicationYear "2009" @default.
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