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- W2092302422 endingPage "108701" @default.
- W2092302422 startingPage "108701" @default.
- W2092302422 abstract "How ATP binding initiates the docking process of kinesin's neck linker is a key question in understanding kinesin mechanisms. By exploiting a molecular dynamics method, we investigate the initial conformation of kinesin's neck linker in its docking process. We find that, in the initial conformation, the neck linker has interactions with β0 and forms a 'cover-neck bundle' structure with β0. From this initial structure, the formation of extra turns and the docking of the cover-neck bundle structure can be achieved. The motor head provides a forward force on the initial cover-neck bundle structure through ATP-induced rotation. This force, together with the hydrophobic interaction of ILE327 with the hydrophobic pocket on the motor head, drives the formation of the extra turn and initiates the neck linker docking process. Based on these findings, a pathway from ATP binding-induced motor head rotation to neck linker docking is proposed." @default.
- W2092302422 created "2016-06-24" @default.
- W2092302422 creator A5041294507 @default.
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- W2092302422 date "2014-10-01" @default.
- W2092302422 modified "2023-10-16" @default.
- W2092302422 title "Initial conformation of kinesin's neck linker" @default.
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- W2092302422 doi "https://doi.org/10.1088/1674-1056/23/10/108701" @default.
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