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• W2092303362 abstract "In CA3 hippocampal neurons of the rat, brief anoxic episodes produce a depolarization which is probably due to a synaptic release of glutamate. Diazoxide, an activator of ATP-sensitive K+ channels (K+ ATP), blocks the anoxic depolarization and has no effect in control oxygenated artificial cerebrospinal fluid. The hormone somatostatin which activates K+ ATP channels in the pancreas also reduces the anoxic depolarization in CA3 neurons. We suggest that drugs that open K+ ATP channels may constitute a novel approach to selectivity reducing the deleterious effects of excessive release of glutamate during anoxia without producing a generalized blockade of glutamatergic synaptic transmission." @default.
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• W2092303362 date "1990-01-01" @default.
• W2092303362 modified "2023-10-18" @default.
• W2092303362 title "Activators of ATP-sensitive K+ channels reduce anoxic depolarization in CA3 hippocampal neurons" @default.
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• W2092303362 doi "https://doi.org/10.1016/0306-4522(90)90191-6" @default.
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