FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092304862> ?p ?o ?g. }

• W2092304862 endingPage "697" @default.
• W2092304862 startingPage "688" @default.
• W2092304862 abstract "XAF1 (XIAP-associated factor 1) is a novel XIAP binding protein that can antagonize XIAP and sensitize cells to other cell death triggers. Our previous results have shown that aberrant hypermethylation of the CpG sites in XAF1 promoter is strongly associated with lower expression of XAF1 in gastric cancers. In our study, we investigated the effect of restoration of XAF1 expression on growth of gastric cancers. We found that the restoration of XAF1 expression suppressed anchorage-dependent and -independent growth and increased sensitivity to TRAIL and drug-induced apoptosis. Stable cell clones expressing XAF1 exhibited delayed tumor initiation in nude mice. Restoration of XAF1 expression mediated by adenovirus vector greatly increased apoptosis in gastric cancer cell lines in a time- and dose-dependent manner and sensitized cancer cells to TRAIL and drugs-induced apoptosis. Adeno-XAF1 transduction induced cell cycle G2/M arrest and upregulated the expression of p21 and downregulated the expression of cyclin B1 and cdc2. Notably, adeno-XAF1 treatment significantly inhibited tumor growth, strongly enhanced the antitumor activity of TRAIL in a gastric cancer xenograft model in vivo, and significantly prolonged the survival time of animals bearing tumor xenografts. Complete eradication of established tumors was achieved on combined treatment with adeno-XAF1 and TRAIL. Our results document that the restoration of XAF1 inhibits gastric tumorigenesis and tumor growth and that XAF1 is a promising candidate for cancer gene therapy. © 2009 UICC" @default.
• W2092304862 created "2016-06-24" @default.
• W2092304862 creator A5002034641 @default.
• W2092304862 creator A5003755362 @default.
• W2092304862 creator A5003944563 @default.
• W2092304862 creator A5010874256 @default.
• W2092304862 creator A5017379226 @default.
• W2092304862 creator A5025234353 @default.
• W2092304862 creator A5030367664 @default.
• W2092304862 creator A5053574481 @default.
• W2092304862 creator A5064912637 @default.
• W2092304862 creator A5070450933 @default.
• W2092304862 creator A5073963268 @default.
• W2092304862 creator A5090532858 @default.
• W2092304862 date "2009-08-01" @default.
• W2092304862 modified "2023-10-17" @default.
• W2092304862 title "Restoration of XAF1 expression induces apoptosis and inhibits tumor growth in gastric cancer" @default.
• W2092304862 cites W1966176339 @default.
• W2092304862 cites W1969150779 @default.
• W2092304862 cites W1975506441 @default.
• W2092304862 cites W1994839373 @default.
• W2092304862 cites W1995484601 @default.
• W2092304862 cites W2001304317 @default.
• W2092304862 cites W2001849902 @default.
• W2092304862 cites W2006077720 @default.
• W2092304862 cites W2008443832 @default.
• W2092304862 cites W2017130328 @default.
• W2092304862 cites W2030776503 @default.
• W2092304862 cites W2031472508 @default.
• W2092304862 cites W2033090895 @default.
• W2092304862 cites W2034269086 @default.
• W2092304862 cites W2048989142 @default.
• W2092304862 cites W2054164997 @default.
• W2092304862 cites W2072304361 @default.
• W2092304862 cites W2072433977 @default.
• W2092304862 cites W2080156248 @default.
• W2092304862 cites W2085628515 @default.
• W2092304862 cites W2087157923 @default.
• W2092304862 cites W2089601738 @default.
• W2092304862 cites W2092830889 @default.
• W2092304862 cites W2094599199 @default.
• W2092304862 cites W2104773672 @default.
• W2092304862 cites W2125715557 @default.
• W2092304862 cites W2125988618 @default.
• W2092304862 cites W2135377755 @default.
• W2092304862 cites W2315415275 @default.
• W2092304862 cites W2750896950 @default.
• W2092304862 doi "https://doi.org/10.1002/ijc.24282" @default.
• W2092304862 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19358264" @default.
• W2092304862 hasPublicationYear "2009" @default.
• W2092304862 type Work @default.
• W2092304862 sameAs 2092304862 @default.
• W2092304862 citedByCount "37" @default.
• W2092304862 countsByYear W20923048622012 @default.
• W2092304862 countsByYear W20923048622013 @default.
• W2092304862 countsByYear W20923048622014 @default.
• W2092304862 countsByYear W20923048622015 @default.
• W2092304862 countsByYear W20923048622016 @default.
• W2092304862 countsByYear W20923048622017 @default.
• W2092304862 countsByYear W20923048622018 @default.
• W2092304862 countsByYear W20923048622019 @default.
• W2092304862 countsByYear W20923048622021 @default.
• W2092304862 countsByYear W20923048622022 @default.
• W2092304862 countsByYear W20923048622023 @default.
• W2092304862 crossrefType "journal-article" @default.
• W2092304862 hasAuthorship W2092304862A5002034641 @default.
• W2092304862 hasAuthorship W2092304862A5003755362 @default.
• W2092304862 hasAuthorship W2092304862A5003944563 @default.
• W2092304862 hasAuthorship W2092304862A5010874256 @default.
• W2092304862 hasAuthorship W2092304862A5017379226 @default.
• W2092304862 hasAuthorship W2092304862A5025234353 @default.
• W2092304862 hasAuthorship W2092304862A5030367664 @default.
• W2092304862 hasAuthorship W2092304862A5053574481 @default.
• W2092304862 hasAuthorship W2092304862A5064912637 @default.
• W2092304862 hasAuthorship W2092304862A5070450933 @default.
• W2092304862 hasAuthorship W2092304862A5073963268 @default.
• W2092304862 hasAuthorship W2092304862A5090532858 @default.
• W2092304862 hasConcept C105696609 @default.
• W2092304862 hasConcept C120504264 @default.
• W2092304862 hasConcept C121608353 @default.
• W2092304862 hasConcept C190283241 @default.
• W2092304862 hasConcept C2777408456 @default.
• W2092304862 hasConcept C2778437423 @default.
• W2092304862 hasConcept C2779707156 @default.
• W2092304862 hasConcept C29537977 @default.
• W2092304862 hasConcept C31573885 @default.
• W2092304862 hasConcept C33195913 @default.
• W2092304862 hasConcept C502942594 @default.
• W2092304862 hasConcept C54355233 @default.
• W2092304862 hasConcept C555283112 @default.
• W2092304862 hasConcept C62112901 @default.
• W2092304862 hasConcept C86803240 @default.
• W2092304862 hasConcept C96232424 @default.
• W2092304862 hasConcept C98424977 @default.
• W2092304862 hasConceptScore W2092304862C105696609 @default.
• W2092304862 hasConceptScore W2092304862C120504264 @default.
• W2092304862 hasConceptScore W2092304862C121608353 @default.
• W2092304862 hasConceptScore W2092304862C190283241 @default.

• next