FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092306502> ?p ?o ?g. }

• W2092306502 endingPage "182" @default.
• W2092306502 startingPage "177" @default.
• W2092306502 abstract "Knowledge on the effects of the additive bronchodilatory effects of short-acting agents on the top of the effect of long-acting bronchodilators is limited. In this trial, we examined the influence of higher than conventional doses of the short-acting inhaled β2-adrenergic agent salbutamol and the short-acting anticholinergic drug ipratropium bromide on bronchodilation induced by a regular treatment with the long-acting anticholinergic drug tiotropium 18 μg/day in 30 patients with stable COPD. On 3 separate days, a dose-response curve to inhaled salbutamol (100 μg puff-1), ipratropium bromide (20 μg puff-1) or placebo was constructed 3 h after inhalation of the last dose of tiotropium, using one puff, one puff, two puffs and two puffs, for a total cumulative dose of 600 μg salbutamol or 120 μg ipratropium bromide. Doses were given at 30-min intervals and measurements made 15 min after each dose. At the highest cumulative dose, salbutamol showed a trend to be more effective than ipratropium bromide in improving FEV1 (0.157 L vs 0.125 L), and reducing sRaw (−4.52 kPa/s vs 3.57 kPa/s), although the differences between the two treatments were always not significant (p > 0.05), whereas there was no substantial difference between the two drugs in changing FVC (0.179 L vs 0.168 L), IC (0.254 L vs 0.240 L), TGV (−0.444 L vs −0.441 L), TLC (−0.334 L vs −0.318 L) and RV (−0.467 L vs −0.498 L). Both drugs did not affect heart rate and SpO2. Our results indicate that there is not much difference in bronchodilation between adding higher than conventional doses of salbutamol or ipratropium bromide to tiotropium in patients with stable COPD. Effective improvement of the pulmonary function may be achieved in such a type of patients by adding salbutamol 600 μg or ipratropium bromide 120 μg to regular tiotropium. These is an interesting finding mainly for those COPD patients suffering from cardiovascular co-morbidities that are at highest risk of myocardial infarction, congestive heart failure, cardiac arrest and sudden cardiac death when treated with elevated doses of a β2-agonist (EudraCT number: 2007-001597-82)." @default.
• W2092306502 created "2016-06-24" @default.
• W2092306502 creator A5019852506 @default.
• W2092306502 creator A5026887019 @default.
• W2092306502 creator A5050164342 @default.
• W2092306502 creator A5059461770 @default.
• W2092306502 creator A5060089859 @default.
• W2092306502 creator A5079833897 @default.
• W2092306502 date "2009-06-01" @default.
• W2092306502 modified "2023-09-23" @default.
• W2092306502 title "Acute effects of higher than standard doses of salbutamol and ipratropium on tiotropium-induced bronchodilation in patients with stable COPD" @default.
• W2092306502 cites W1853608828 @default.
• W2092306502 cites W1974215693 @default.
• W2092306502 cites W1978722138 @default.
• W2092306502 cites W1980922801 @default.
• W2092306502 cites W1985000746 @default.
• W2092306502 cites W2001549925 @default.
• W2092306502 cites W2011540805 @default.
• W2092306502 cites W2048772177 @default.
• W2092306502 cites W2058946057 @default.
• W2092306502 cites W2068467067 @default.
• W2092306502 cites W2082198827 @default.
• W2092306502 cites W2095521766 @default.
• W2092306502 cites W2107045802 @default.
• W2092306502 cites W2110937140 @default.
• W2092306502 cites W2113026917 @default.
• W2092306502 cites W2119061500 @default.
• W2092306502 cites W2121653483 @default.
• W2092306502 cites W2123477530 @default.
• W2092306502 cites W2141034778 @default.
• W2092306502 cites W2143454168 @default.
• W2092306502 cites W2149199480 @default.
• W2092306502 cites W2158530076 @default.
• W2092306502 cites W2163053179 @default.
• W2092306502 cites W2166432084 @default.
• W2092306502 cites W2168025678 @default.
• W2092306502 cites W2170923355 @default.
• W2092306502 cites W2171932083 @default.
• W2092306502 cites W2469684958 @default.
• W2092306502 cites W4211263216 @default.
• W2092306502 doi "https://doi.org/10.1016/j.pupt.2008.10.010" @default.
• W2092306502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19038356" @default.
• W2092306502 hasPublicationYear "2009" @default.
• W2092306502 type Work @default.
• W2092306502 sameAs 2092306502 @default.
• W2092306502 citedByCount "15" @default.
• W2092306502 countsByYear W20923065022012 @default.
• W2092306502 countsByYear W20923065022013 @default.
• W2092306502 countsByYear W20923065022014 @default.
• W2092306502 countsByYear W20923065022017 @default.
• W2092306502 countsByYear W20923065022020 @default.
• W2092306502 crossrefType "journal-article" @default.
• W2092306502 hasAuthorship W2092306502A5019852506 @default.
• W2092306502 hasAuthorship W2092306502A5026887019 @default.
• W2092306502 hasAuthorship W2092306502A5050164342 @default.
• W2092306502 hasAuthorship W2092306502A5059461770 @default.
• W2092306502 hasAuthorship W2092306502A5060089859 @default.
• W2092306502 hasAuthorship W2092306502A5079833897 @default.
• W2092306502 hasBestOaLocation W20923065022 @default.
• W2092306502 hasConcept C126322002 @default.
• W2092306502 hasConcept C2776042228 @default.
• W2092306502 hasConcept C2776780178 @default.
• W2092306502 hasConcept C2776954882 @default.
• W2092306502 hasConcept C2777394947 @default.
• W2092306502 hasConcept C2778689640 @default.
• W2092306502 hasConcept C2780532441 @default.
• W2092306502 hasConcept C2781018748 @default.
• W2092306502 hasConcept C2908646376 @default.
• W2092306502 hasConcept C2909577894 @default.
• W2092306502 hasConcept C42219234 @default.
• W2092306502 hasConcept C71924100 @default.
• W2092306502 hasConcept C98274493 @default.
• W2092306502 hasConceptScore W2092306502C126322002 @default.
• W2092306502 hasConceptScore W2092306502C2776042228 @default.
• W2092306502 hasConceptScore W2092306502C2776780178 @default.
• W2092306502 hasConceptScore W2092306502C2776954882 @default.
• W2092306502 hasConceptScore W2092306502C2777394947 @default.
• W2092306502 hasConceptScore W2092306502C2778689640 @default.
• W2092306502 hasConceptScore W2092306502C2780532441 @default.
• W2092306502 hasConceptScore W2092306502C2781018748 @default.
• W2092306502 hasConceptScore W2092306502C2908646376 @default.
• W2092306502 hasConceptScore W2092306502C2909577894 @default.
• W2092306502 hasConceptScore W2092306502C42219234 @default.
• W2092306502 hasConceptScore W2092306502C71924100 @default.
• W2092306502 hasConceptScore W2092306502C98274493 @default.
• W2092306502 hasIssue "3" @default.
• W2092306502 hasLocation W20923065021 @default.
• W2092306502 hasLocation W20923065022 @default.
• W2092306502 hasLocation W20923065023 @default.
• W2092306502 hasLocation W20923065024 @default.
• W2092306502 hasOpenAccess W2092306502 @default.
• W2092306502 hasPrimaryLocation W20923065021 @default.
• W2092306502 hasRelatedWork W1180164227 @default.
• W2092306502 hasRelatedWork W1978807627 @default.
• W2092306502 hasRelatedWork W1985443477 @default.
• W2092306502 hasRelatedWork W2027739149 @default.
• W2092306502 hasRelatedWork W2092306502 @default.
• W2092306502 hasRelatedWork W2116148510 @default.

• next