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- W2092307622 abstract "The production of interleukin 1 (IL-1) by lipopolysaccharide (LPS)-stimulated myelomonocytic cell lines ML-1, THP-1 and PL-21 was significantly enhanced by the addition of insulin, insulin-like growth factor (IGF)-I or IGF-II into the cell cultures. The IL-1 activity in the supernatants from cell cultures stimulated with LPS and insulin was completely neutralized by anti-IL-1β antibody. Anti-IL-1α antibody had no inhibitory effect. Insulin itself did not stimulate IL-1β production directly, but increased it in the mitogen activated cells. However, insulin had no enhancing effect on the production of IL-1α by human T cell lymphotropic virus-I (HTLV-I)-infected T cell lines or on IL-2 production by mitogen-stimulated leukemia T cell lines. Thus, insulin and its related cytokines are shown here as other molecules selectively modulating the production of IL-1β in myelomonocytic cell lines." @default.
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- W2092307622 date "1992-12-01" @default.
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- W2092307622 title "Selective enhancement of interleukin 1β production in myelomonocytic cell lines by insulin and its related cytokines" @default.
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- W2092307622 doi "https://doi.org/10.1016/0165-2478(92)90220-i" @default.
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