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- W2092309945 abstract "Mammary tumours were induced in female Sprague-Dawley rats by a single oral dose of 20 mg of 7,12-dimethylbenz(a)anthracene (DMBA) given when the rats were 50 days old. The tumours were of three main types: non-secreting adenomata, milk-secreting adenomata and fibro-adenomata. The histological appearance of the nonsecreting adenomata was similar to that of tumours induced by 3-methylcholanthrene. The appearance of the milk-secreting adenomata, with prominent vacuoles in the epithelial cells and milk filling the lumen of the acini, resembled the picture of the normal mammary gland of the rat in late pregnancy. The tumours which appeared earliest were the non-secreting adenomata, and most of these tumours developed during the first 6 months after administration of DMBA. In the first 5 months milk-secreting adenomata and fibro-adenomata were rare, but after this time nearly all the tumours which developed were either milk-secreting adenomata or fibro-adenomata. The milk-secreting adenomata, though late in appearing, were the most numerous of all the tumours induced. The reasons for describing the tumours as adenomata rather than carcinomata are given. Hypophysectomy was very effective in causing regression of the non-secreting adenomata. Less successful results were obtained by removal of the ovaries and adrenal glands." @default.
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- W2092309945 date "1967-03-15" @default.
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- W2092309945 title "Further studies on mammary tumours induced in rats by 7,12-dimethylbenz(a)anthracene (DMBA)" @default.
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- W2092309945 doi "https://doi.org/10.1002/ijc.2910020211" @default.
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