Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092310080> ?p ?o ?g. }
- W2092310080 endingPage "97" @default.
- W2092310080 startingPage "92" @default.
- W2092310080 abstract "Progesterone (P) plays an important role in seizure susceptibility in women with epilepsy. Preclinical and experimental studies suggest that P appears to interrupt epileptogenesis, which is a process whereby a normal brain becomes progressively susceptible to recurrent, unprovoked seizures due to precipitating risk factors. Progesterone has not been investigated widely for its potential disease-modifying activity in epileptogenic models. Recently, P has been shown to exert disease-modifying effects in the kindling model of epileptogenesis. However, the mechanisms underlying the protective effects of P against epileptogenesis remain unclear. In this study, we investigated the role of P-derived neurosteroids in the disease-modifying activity of P. It is hypothesized that 5α-reductase converts P to allopregnanolone and related neurosteroids that retard epileptogenesis in the brain. To test this hypothesis, we utilized the mouse hippocampus kindling model of epileptogenesis and investigated the effect of finasteride, a 5α-reductase and neurosteroid synthesis inhibitor. Progesterone markedly retarded the development of epileptogenesis and inhibited the rate of kindling acquisition to elicit stage 5 seizures. Pretreatment with finasteride led to complete inhibition of the P-induced retardation of the limbic epileptogenesis in mice. Finasteride did not significantly influence the acute seizure expression in fully kindled mice expressing stage 5 seizures. Thus, neurosteroids that potentiate phasic and tonic inhibition in the hippocampus, such as allopregnanolone, may mediate the disease-modifying effect of P, indicating a new role of neurosteroids in acquired limbic epileptogenesis and temporal lobe epilepsy." @default.
- W2092310080 created "2016-06-24" @default.
- W2092310080 creator A5002821906 @default.
- W2092310080 creator A5041588481 @default.
- W2092310080 date "2012-09-01" @default.
- W2092310080 modified "2023-09-25" @default.
- W2092310080 title "Finasteride inhibits the disease-modifying activity of progesterone in the hippocampus kindling model of epileptogenesis" @default.
- W2092310080 cites W15119525 @default.
- W2092310080 cites W1520748992 @default.
- W2092310080 cites W1972888313 @default.
- W2092310080 cites W1973115552 @default.
- W2092310080 cites W1983034344 @default.
- W2092310080 cites W1984578913 @default.
- W2092310080 cites W1987215794 @default.
- W2092310080 cites W1987762375 @default.
- W2092310080 cites W1999217140 @default.
- W2092310080 cites W1999335299 @default.
- W2092310080 cites W2000341627 @default.
- W2092310080 cites W2006270043 @default.
- W2092310080 cites W2006676831 @default.
- W2092310080 cites W2011191676 @default.
- W2092310080 cites W2013777991 @default.
- W2092310080 cites W2020886601 @default.
- W2092310080 cites W2023261925 @default.
- W2092310080 cites W2024740082 @default.
- W2092310080 cites W2031193882 @default.
- W2092310080 cites W2031648971 @default.
- W2092310080 cites W2037919944 @default.
- W2092310080 cites W2054060583 @default.
- W2092310080 cites W2061028746 @default.
- W2092310080 cites W2066456246 @default.
- W2092310080 cites W2066907188 @default.
- W2092310080 cites W2075127739 @default.
- W2092310080 cites W2077468380 @default.
- W2092310080 cites W2079783599 @default.
- W2092310080 cites W2087616446 @default.
- W2092310080 cites W2091060078 @default.
- W2092310080 cites W2095492353 @default.
- W2092310080 cites W2098185331 @default.
- W2092310080 cites W2103946141 @default.
- W2092310080 cites W2107550955 @default.
- W2092310080 cites W2112264559 @default.
- W2092310080 cites W2121587872 @default.
- W2092310080 cites W2127146014 @default.
- W2092310080 cites W2142169831 @default.
- W2092310080 cites W2148377354 @default.
- W2092310080 cites W2160297083 @default.
- W2092310080 cites W2167319777 @default.
- W2092310080 cites W2172284528 @default.
- W2092310080 cites W3173768076 @default.
- W2092310080 doi "https://doi.org/10.1016/j.yebeh.2012.05.024" @default.
- W2092310080 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3444667" @default.
- W2092310080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22835430" @default.
- W2092310080 hasPublicationYear "2012" @default.
- W2092310080 type Work @default.
- W2092310080 sameAs 2092310080 @default.
- W2092310080 citedByCount "27" @default.
- W2092310080 countsByYear W20923100802013 @default.
- W2092310080 countsByYear W20923100802014 @default.
- W2092310080 countsByYear W20923100802015 @default.
- W2092310080 countsByYear W20923100802016 @default.
- W2092310080 countsByYear W20923100802017 @default.
- W2092310080 countsByYear W20923100802018 @default.
- W2092310080 countsByYear W20923100802019 @default.
- W2092310080 countsByYear W20923100802020 @default.
- W2092310080 countsByYear W20923100802021 @default.
- W2092310080 countsByYear W20923100802022 @default.
- W2092310080 countsByYear W20923100802023 @default.
- W2092310080 crossrefType "journal-article" @default.
- W2092310080 hasAuthorship W2092310080A5002821906 @default.
- W2092310080 hasAuthorship W2092310080A5041588481 @default.
- W2092310080 hasBestOaLocation W20923100802 @default.
- W2092310080 hasConcept C100691959 @default.
- W2092310080 hasConcept C121608353 @default.
- W2092310080 hasConcept C126322002 @default.
- W2092310080 hasConcept C134018914 @default.
- W2092310080 hasConcept C15744967 @default.
- W2092310080 hasConcept C168258287 @default.
- W2092310080 hasConcept C169760540 @default.
- W2092310080 hasConcept C170493617 @default.
- W2092310080 hasConcept C2775874879 @default.
- W2092310080 hasConcept C2776235491 @default.
- W2092310080 hasConcept C2778186239 @default.
- W2092310080 hasConcept C2778302826 @default.
- W2092310080 hasConcept C2778338918 @default.
- W2092310080 hasConcept C2781161787 @default.
- W2092310080 hasConcept C44796713 @default.
- W2092310080 hasConcept C57236427 @default.
- W2092310080 hasConcept C71924100 @default.
- W2092310080 hasConceptScore W2092310080C100691959 @default.
- W2092310080 hasConceptScore W2092310080C121608353 @default.
- W2092310080 hasConceptScore W2092310080C126322002 @default.
- W2092310080 hasConceptScore W2092310080C134018914 @default.
- W2092310080 hasConceptScore W2092310080C15744967 @default.
- W2092310080 hasConceptScore W2092310080C168258287 @default.
- W2092310080 hasConceptScore W2092310080C169760540 @default.
- W2092310080 hasConceptScore W2092310080C170493617 @default.
- W2092310080 hasConceptScore W2092310080C2775874879 @default.