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• W2092322847 abstract "To clarify the mechanisms underlying the positive inotropic action of endothelin-1 (ET-1), we investigated the effect of ET-1 on twitch cell shortening and the Ca2+ transient in rat isolated ventricular myocytes loaded with a fluorescent Ca2+ indicator indo-1. There was a cell-to-cell heterogeneity in response to ET-1. ET-1 (100 nm) increased twitch cell shortening in only 6 of 14 cells (44 %) and the increase in twitch cell shortening was always accompanied by an increase in the amplitude of the Ca2+ transient. The ETA- and ETB-receptors antagonist TAK-044 (100 nm) almost reversed both the ET-1-induced increases in twitch cell shortening and in the Ca2+ transient. In the ET-1 non-responding cells, the amplitude of the Ca2+ transient never increased. Intracellular pH slightly increased (∼0.08 unit) after 30 min perfusion of ET-1 in rat ventricular myocytes. However, ET-1 did not change the myofilament responsiveness to Ca2+, which was assessed by (1) the relationship between the Ca2+ transient amplitude and twitch cell shortening, and by (2) the Ca2+ transient-cell shortening phase plane diagram during negative staircase. We concluded that there was a cell-to-cell heterogeneity in the positive inotropic effect of ET-1, and that the ET-receptor-mediated positive inotropic effect was mainly due to an increase in the Ca2+ transient amplitude rather than to an increase in myofilament responsiveness to Ca2+. British Journal of Pharmacology (1998) 123, 1343–1350; doi:10.1038/sj.bjp.0701743" @default.
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• W2092322847 date "1998-04-01" @default.
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• W2092322847 title "Heterogeneity and underlying mechanism for inotropic action of endothelin-1 in rat ventricular myocytes" @default.
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• W2092322847 doi "https://doi.org/10.1038/sj.bjp.0701743" @default.
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