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• W2092323746 abstract "In order to determine whether angiogenesis is a prognostic marker in lung cancer, we performed a systematic review of the literature to assess the prognostic value on survival of microvessel count in patients with lung cancer. Published studies were identified by an electronic search in order to aggregate survival results, after a methodological assessment using a quality scale designed by the European Lung Cancer Working Party. To be eligible, a study had to deal with microvessel count assessment in lung cancer patients on the primary site and to provide survival analysis according to microvessel count expression. Microvessel count has been assessed on surgical samples by immunohistochemistry using factor VIII in 14 studies, CD34 in 10 and CD31 in eight. Respectively 1866, 1440 and 1093 non-small cell lung cancer patients were considered. The overall median quality scores were respectively 52, 59 and 59% for studies assessing microvessel count via factor VIII, CD34 and CD31, without significant difference between studies evaluable or not for meta-analysis nor between studies with significant or non significant results. Seven ‘factor VIII’ studies, nine ‘CD34’ and seven ‘CD31’ provided sufficient data allowing a meta-analysis on survival and were evaluable for results aggregation. This showed that a high microvessel count in the primitive lung tumour was a statistically significant poor prognostic factor for survival in non small cell lung cancer whatever it was assessed by factor VIII (HR: 1.81; 95% CI: 1.16–2.84), CD34 (HR: 1.99; 95% CI: 1.53–2.58) or CD31 (HR: 1.80; 95% CI: 1.10–2.96). Variations in survival among the individual studies can be explained in addition to patients selection criteria by the heterogeneous methodologies used to stain and count microvessels: different antibody clones, identification of ‘hotspots’, Weidner or Chalkey counting method, cut-off selection. Microvessel count, reflecting the angiogenesis, appears to be a poor prognostic factor for survival in surgically treated non small cell lung cancer but standardisation of angiogenesis assessment by the microvessel count is necessary." @default.
• W2092323746 created "2016-06-24" @default.
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• W2092323746 date "2002-09-01" @default.
• W2092323746 modified "2023-10-10" @default.
• W2092323746 title "The role of microvessel density on the survival of patients with lung cancer: a systematic review of the literature with meta-analysis" @default.
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• W2092323746 cites W1514879568 @default.
• W2092323746 cites W1525411967 @default.
• W2092323746 cites W1596286692 @default.
• W2092323746 cites W1753603995 @default.
• W2092323746 cites W1835948467 @default.
• W2092323746 cites W1874274830 @default.
• W2092323746 cites W1914679554 @default.
• W2092323746 cites W1960304662 @default.
• W2092323746 cites W1964087167 @default.
• W2092323746 cites W1964210305 @default.
• W2092323746 cites W1966953116 @default.
• W2092323746 cites W1967947451 @default.
• W2092323746 cites W1973498312 @default.
• W2092323746 cites W1973717102 @default.
• W2092323746 cites W1978347107 @default.
• W2092323746 cites W1980300818 @default.
• W2092323746 cites W1980803670 @default.
• W2092323746 cites W1982533441 @default.
• W2092323746 cites W1986944960 @default.
• W2092323746 cites W1990130976 @default.
• W2092323746 cites W1996761484 @default.
• W2092323746 cites W2002219767 @default.
• W2092323746 cites W2002265561 @default.
• W2092323746 cites W2003032376 @default.
• W2092323746 cites W2005177011 @default.
• W2092323746 cites W2005316524 @default.
• W2092323746 cites W2012149684 @default.
• W2092323746 cites W2016791457 @default.
• W2092323746 cites W2021716162 @default.
• W2092323746 cites W2024955180 @default.
• W2092323746 cites W2028574235 @default.
• W2092323746 cites W2030126960 @default.
• W2092323746 cites W2030196526 @default.
• W2092323746 cites W2036142151 @default.
• W2092323746 cites W2037761545 @default.
• W2092323746 cites W2041085319 @default.
• W2092323746 cites W2043044740 @default.
• W2092323746 cites W2048939313 @default.
• W2092323746 cites W2052182008 @default.
• W2092323746 cites W2059276755 @default.
• W2092323746 cites W2063824904 @default.
• W2092323746 cites W2064297621 @default.
• W2092323746 cites W2071289415 @default.
• W2092323746 cites W2074070420 @default.
• W2092323746 cites W2075642745 @default.
• W2092323746 cites W2075990213 @default.
• W2092323746 cites W2076444237 @default.
• W2092323746 cites W2086437357 @default.
• W2092323746 cites W2088301689 @default.
• W2092323746 cites W2089395792 @default.
• W2092323746 cites W2090032922 @default.
• W2092323746 cites W2092815005 @default.
• W2092323746 cites W2101299963 @default.
• W2092323746 cites W2111585211 @default.
• W2092323746 cites W2113257521 @default.
• W2092323746 cites W2118674322 @default.
• W2092323746 cites W2127561264 @default.
• W2092323746 cites W2134855461 @default.
• W2092323746 cites W2138605082 @default.
• W2092323746 cites W2147312210 @default.
• W2092323746 cites W2151220251 @default.
• W2092323746 cites W2158743409 @default.
• W2092323746 cites W2161524172 @default.
• W2092323746 cites W2171981087 @default.
• W2092323746 cites W2319962899 @default.
• W2092323746 cites W2339444986 @default.
• W2092323746 cites W2399035519 @default.
• W2092323746 cites W2400871210 @default.
• W2092323746 cites W2401850857 @default.
• W2092323746 cites W2407857539 @default.
• W2092323746 cites W2427961785 @default.
• W2092323746 cites W649313618 @default.
• W2092323746 cites W83133541 @default.
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• W2092323746 doi "https://doi.org/10.1038/sj.bjc.6600551" @default.
• W2092323746 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2364252" @default.
• W2092323746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12232748" @default.
• W2092323746 hasPublicationYear "2002" @default.
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