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- W2092338667 abstract "Sex assignment of patients with disorders of somatosexual differentiation is a controversial topic. The aim is to enable the patient to develop a stable gender identity during childhood, adolescence and adulthood. Enormous advances have recently been made in our knowledge of the molecular mechanisms of sexual differentiation and it is understood that long-term outcome may depend on the underlying diagnosis. There is increasing evidence that genital development is dependent on the action of androgenic steroids; moreover, both androgens and oestrogens may have an impact on other developing organs including neuronal structures such as the brain. Long-term outcome studies on the various intersexuality disorders are desperately needed in order to establish a basis for evidence-based medicine regarding sex assignment and treatment options. Premature decisions leading to irreversible interventions before an accurate diagnosis has been established must be avoided." @default.
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- W2092338667 date "2005-01-01" @default.
- W2092338667 modified "2023-09-25" @default.
- W2092338667 title "The Basis of Gender Assignment in Disorders of Somatosexual Differentiation" @default.
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- W2092338667 doi "https://doi.org/10.1159/000087748" @default.
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