FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092339636> ?p ?o ?g. }

• W2092339636 endingPage "477" @default.
• W2092339636 startingPage "465" @default.
• W2092339636 abstract "To investigate the effects of diltiazem, an L-type calcium channel blocker, and propafenone, a sodium channel blocker, on the inactivation and recovery kinetics of fKv1.4, a potassium channel that generates the cardiac transient outward potassium current. The cRNA for fKv1.4ΔN, an N-terminal deleted mutant of the ferret Kv1.4 potassium channel, was injected into Xenopus oocytes to express the fKv1.4ΔN channel in these cells. Currents were recorded using a two electrode voltage clamp technique. Diltiazem (10 to 1000 μmol/L) inhibited the fKv1.4ΔN channel in a frequency-dependent, voltage-dependent, and concentration-dependent manner, suggesting an open channel block. The IC50 was 241.04±23.06 μmol/L for the fKv1.4ΔN channel (at +50 mV), and propafenone (10 to 500 μmol/L) showed a similar effect (IC50=103.68±10.13 μmol/L). After application of diltiazem and propafenone, fKv1.4ΔN inactivation was bi-exponential, with a faster drug-induced inactivation and a slower C-type inactivation. Diltiazem increased the C-type inactivation rate and slowed recovery in fKv1.4ΔN channels. However, propafenone had no effect on either the slow inactivation time constant or the recovery. Diltiazem and propafenone accelerate the inactivation of the Kv1.4ΔN channel by binding to the open state of the channel. Unlike propafenone, diltiazem slows the recovery of the Kv1.4ΔN channel." @default.
• W2092339636 created "2016-06-24" @default.
• W2092339636 creator A5011090841 @default.
• W2092339636 creator A5052526481 @default.
• W2092339636 creator A5053217157 @default.
• W2092339636 creator A5070096266 @default.
• W2092339636 creator A5070152973 @default.
• W2092339636 date "2011-04-01" @default.
• W2092339636 modified "2023-10-03" @default.
• W2092339636 title "Effects of diltiazem and propafenone on the inactivation and recovery kinetics of fKv1.4 channel currents expressed in Xenopus oocytes" @default.
• W2092339636 cites W1966667742 @default.
• W2092339636 cites W1969870358 @default.
• W2092339636 cites W1972259953 @default.
• W2092339636 cites W1978701105 @default.
• W2092339636 cites W1997711484 @default.
• W2092339636 cites W2007832680 @default.
• W2092339636 cites W2018351366 @default.
• W2092339636 cites W2024649309 @default.
• W2092339636 cites W2052310626 @default.
• W2092339636 cites W2055429929 @default.
• W2092339636 cites W2060579130 @default.
• W2092339636 cites W2082668900 @default.
• W2092339636 cites W2089123543 @default.
• W2092339636 cites W2092488437 @default.
• W2092339636 cites W2097478467 @default.
• W2092339636 cites W2100992840 @default.
• W2092339636 cites W2108369925 @default.
• W2092339636 cites W2108765087 @default.
• W2092339636 cites W2120642757 @default.
• W2092339636 cites W2124805101 @default.
• W2092339636 cites W2127019778 @default.
• W2092339636 cites W2130968993 @default.
• W2092339636 cites W2136463260 @default.
• W2092339636 cites W2147296371 @default.
• W2092339636 cites W2153945369 @default.
• W2092339636 cites W2163427383 @default.
• W2092339636 cites W2909258322 @default.
• W2092339636 doi "https://doi.org/10.1038/aps.2010.234" @default.
• W2092339636 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4001977" @default.
• W2092339636 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21468083" @default.
• W2092339636 hasPublicationYear "2011" @default.
• W2092339636 type Work @default.
• W2092339636 sameAs 2092339636 @default.
• W2092339636 citedByCount "4" @default.
• W2092339636 countsByYear W20923396362012 @default.
• W2092339636 countsByYear W20923396362013 @default.
• W2092339636 countsByYear W20923396362015 @default.
• W2092339636 crossrefType "journal-article" @default.
• W2092339636 hasAuthorship W2092339636A5011090841 @default.
• W2092339636 hasAuthorship W2092339636A5052526481 @default.
• W2092339636 hasAuthorship W2092339636A5053217157 @default.
• W2092339636 hasAuthorship W2092339636A5070096266 @default.
• W2092339636 hasAuthorship W2092339636A5070152973 @default.
• W2092339636 hasBestOaLocation W20923396361 @default.
• W2092339636 hasConcept C104317684 @default.
• W2092339636 hasConcept C12554922 @default.
• W2092339636 hasConcept C126322002 @default.
• W2092339636 hasConcept C147944092 @default.
• W2092339636 hasConcept C170493617 @default.
• W2092339636 hasConcept C178790620 @default.
• W2092339636 hasConcept C185592680 @default.
• W2092339636 hasConcept C202751555 @default.
• W2092339636 hasConcept C2776741139 @default.
• W2092339636 hasConcept C2777752497 @default.
• W2092339636 hasConcept C2778457506 @default.
• W2092339636 hasConcept C2779161974 @default.
• W2092339636 hasConcept C2779535977 @default.
• W2092339636 hasConcept C2781472538 @default.
• W2092339636 hasConcept C50952357 @default.
• W2092339636 hasConcept C519063684 @default.
• W2092339636 hasConcept C537181965 @default.
• W2092339636 hasConcept C55493867 @default.
• W2092339636 hasConcept C71924100 @default.
• W2092339636 hasConcept C83743174 @default.
• W2092339636 hasConcept C86803240 @default.
• W2092339636 hasConcept C98274493 @default.
• W2092339636 hasConceptScore W2092339636C104317684 @default.
• W2092339636 hasConceptScore W2092339636C12554922 @default.
• W2092339636 hasConceptScore W2092339636C126322002 @default.
• W2092339636 hasConceptScore W2092339636C147944092 @default.
• W2092339636 hasConceptScore W2092339636C170493617 @default.
• W2092339636 hasConceptScore W2092339636C178790620 @default.
• W2092339636 hasConceptScore W2092339636C185592680 @default.
• W2092339636 hasConceptScore W2092339636C202751555 @default.
• W2092339636 hasConceptScore W2092339636C2776741139 @default.
• W2092339636 hasConceptScore W2092339636C2777752497 @default.
• W2092339636 hasConceptScore W2092339636C2778457506 @default.
• W2092339636 hasConceptScore W2092339636C2779161974 @default.
• W2092339636 hasConceptScore W2092339636C2779535977 @default.
• W2092339636 hasConceptScore W2092339636C2781472538 @default.
• W2092339636 hasConceptScore W2092339636C50952357 @default.
• W2092339636 hasConceptScore W2092339636C519063684 @default.
• W2092339636 hasConceptScore W2092339636C537181965 @default.
• W2092339636 hasConceptScore W2092339636C55493867 @default.
• W2092339636 hasConceptScore W2092339636C71924100 @default.
• W2092339636 hasConceptScore W2092339636C83743174 @default.
• W2092339636 hasConceptScore W2092339636C86803240 @default.
• W2092339636 hasConceptScore W2092339636C98274493 @default.

• next