FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092350536> ?p ?o ?g. }

• W2092350536 endingPage "46" @default.
• W2092350536 startingPage "36" @default.
• W2092350536 abstract "Macrophage-activating lipopeptide-2 (MALP-2) has been identified as the pathogen-associated molecular pattern of Mycoplasma fermentans, which causes stimulation of the innate immune system through the activation of the heterodimeric Toll-like receptors (TLRs) 2 and 6. Based on the reported protective effects of MALP-2 on healing of skin wounds, the central goal of this study was to evaluate the capacity of MALP-2 to induce a localized inflammatory response in an established model of a subcutaneous air pouch. Injections of MALP-2 into the pouch caused fever and some components of sickness behavior in rats. At the subcutaneous site of localized inflammation, a massive formation of tumor necrosis factor-alpha (TNF), interleukin-6 (IL-6), and prostaglandin E2 (PGE2) could be demonstrated in response to injections of MALP-2. Moderate amounts of IL-6 and PGE2 seemed to enter the systemic circulation of MALP-2-treated rats. The IL-6, which appeared in the blood after injection of MALP-2 into the air pouch was sufficient to cause a direct activation of brain cells in areas which lack a complete blood-brain barrier, namely in the sensory circumventricular organs (sCVOs), the organum vasculosum laminae terminalis (OVLT), the subfornical organ (SFO), and the area postrema (AP). The stimulation of cells at these brain sites was revealed by demonstration of a nuclear translocation of the transcription factor STAT3 (signal transducer and activator of transcription 3). Corresponding to the circulating levels of IL-6, the nuclear STAT3 activation of cells within the sCVOs was much less pronounced after local subcutaneous when compared to systemic treatment with MALP-2. In conclusion, cells within the subcutaneous compartment are activated by the TLR2/6 agonist MALP-2. Fever and sickness behavior induced by injection of MALP-2 into subcutaneous tissue may, in part, be mediated by a spillover of IL-6 from the subcutaneous site of inflammation into the blood to cause activation of brain sites which are implicated in the manifestation of these illness responses." @default.
• W2092350536 created "2016-06-24" @default.
• W2092350536 creator A5053143351 @default.
• W2092350536 creator A5062383482 @default.
• W2092350536 creator A5076407347 @default.
• W2092350536 creator A5086779853 @default.
• W2092350536 creator A5086781164 @default.
• W2092350536 creator A5091282541 @default.
• W2092350536 date "2008-04-01" @default.
• W2092350536 modified "2023-10-15" @default.
• W2092350536 title "Macrophage-activating lipopeptide-2 (MALP-2) induces a localized inflammatory response in rats resulting in activation of brain sites implicated in fever" @default.
• W2092350536 cites W1503577663 @default.
• W2092350536 cites W162257389 @default.
• W2092350536 cites W1900852307 @default.
• W2092350536 cites W1967760510 @default.
• W2092350536 cites W1969411212 @default.
• W2092350536 cites W1978956801 @default.
• W2092350536 cites W1981161904 @default.
• W2092350536 cites W1988606795 @default.
• W2092350536 cites W1996387328 @default.
• W2092350536 cites W2001354194 @default.
• W2092350536 cites W2005032514 @default.
• W2092350536 cites W2011584176 @default.
• W2092350536 cites W2035121795 @default.
• W2092350536 cites W2043435771 @default.
• W2092350536 cites W2045994657 @default.
• W2092350536 cites W2051285131 @default.
• W2092350536 cites W2052538445 @default.
• W2092350536 cites W2054415514 @default.
• W2092350536 cites W2065248782 @default.
• W2092350536 cites W2065496760 @default.
• W2092350536 cites W2065817328 @default.
• W2092350536 cites W2069402589 @default.
• W2092350536 cites W2070839349 @default.
• W2092350536 cites W2071221726 @default.
• W2092350536 cites W2077321360 @default.
• W2092350536 cites W2077343216 @default.
• W2092350536 cites W2082864276 @default.
• W2092350536 cites W2086179163 @default.
• W2092350536 cites W2089373045 @default.
• W2092350536 cites W2091676080 @default.
• W2092350536 cites W2092297430 @default.
• W2092350536 cites W2096052453 @default.
• W2092350536 cites W2102028071 @default.
• W2092350536 cites W2105070448 @default.
• W2092350536 cites W2122248986 @default.
• W2092350536 cites W2128215007 @default.
• W2092350536 cites W2142478848 @default.
• W2092350536 cites W2145584783 @default.
• W2092350536 cites W2156788946 @default.
• W2092350536 cites W2162607473 @default.
• W2092350536 cites W4230962636 @default.
• W2092350536 cites W4235410276 @default.
• W2092350536 doi "https://doi.org/10.1016/j.brainres.2008.02.021" @default.
• W2092350536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18353287" @default.
• W2092350536 hasPublicationYear "2008" @default.
• W2092350536 type Work @default.
• W2092350536 sameAs 2092350536 @default.
• W2092350536 citedByCount "20" @default.
• W2092350536 countsByYear W20923505362012 @default.
• W2092350536 countsByYear W20923505362013 @default.
• W2092350536 countsByYear W20923505362014 @default.
• W2092350536 countsByYear W20923505362016 @default.
• W2092350536 countsByYear W20923505362017 @default.
• W2092350536 countsByYear W20923505362019 @default.
• W2092350536 countsByYear W20923505362020 @default.
• W2092350536 countsByYear W20923505362021 @default.
• W2092350536 countsByYear W20923505362022 @default.
• W2092350536 crossrefType "journal-article" @default.
• W2092350536 hasAuthorship W2092350536A5053143351 @default.
• W2092350536 hasAuthorship W2092350536A5062383482 @default.
• W2092350536 hasAuthorship W2092350536A5076407347 @default.
• W2092350536 hasAuthorship W2092350536A5086779853 @default.
• W2092350536 hasAuthorship W2092350536A5086781164 @default.
• W2092350536 hasAuthorship W2092350536A5091282541 @default.
• W2092350536 hasConcept C126322002 @default.
• W2092350536 hasConcept C134018914 @default.
• W2092350536 hasConcept C170493617 @default.
• W2092350536 hasConcept C17991360 @default.
• W2092350536 hasConcept C203014093 @default.
• W2092350536 hasConcept C24998067 @default.
• W2092350536 hasConcept C2775857624 @default.
• W2092350536 hasConcept C2776459250 @default.
• W2092350536 hasConcept C2776914184 @default.
• W2092350536 hasConcept C2777619780 @default.
• W2092350536 hasConcept C2778402981 @default.
• W2092350536 hasConcept C2908929049 @default.
• W2092350536 hasConcept C529278444 @default.
• W2092350536 hasConcept C71924100 @default.
• W2092350536 hasConcept C86803240 @default.
• W2092350536 hasConcept C8891405 @default.
• W2092350536 hasConceptScore W2092350536C126322002 @default.
• W2092350536 hasConceptScore W2092350536C134018914 @default.
• W2092350536 hasConceptScore W2092350536C170493617 @default.
• W2092350536 hasConceptScore W2092350536C17991360 @default.
• W2092350536 hasConceptScore W2092350536C203014093 @default.
• W2092350536 hasConceptScore W2092350536C24998067 @default.
• W2092350536 hasConceptScore W2092350536C2775857624 @default.

• next