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• W2092360041 abstract "Heterogeneous nuclear ribonucleoproteins (hnRNPs) are thought to be involved in pre-mRNA processing. hnRNP-U, also termed scaffold attachment factor A (SAF-A), binds to pre-mRNA and nuclear matrix/scaffold attachment region DNA elements. However, its role in the regulation of gene expression is as yet poorly understood. In the present study, we show that hnRNP-U specifically enhances the expression of tumor necrosis factor alpha mRNA by increasing its stability, possibly through binding to the 3' untranslated region. We also show that hnRNP-U enhances the expression of several other genes as well, including GADD45A, HEXIM1, HOXA2, IER3, NHLH2, and ZFY, by binding to and stabilizing these mRNAs. These results suggest that hnRNP-U enhances the expression of specific genes by regulating mRNA stability." @default.
• W2092360041 created "2016-06-24" @default.
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• W2092360041 date "2006-12-04" @default.
• W2092360041 modified "2023-10-03" @default.
• W2092360041 title "hnRNP-U enhances the expression of specific genes by stabilizing mRNA" @default.
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• W2092360041 doi "https://doi.org/10.1016/j.febslet.2006.11.062" @default.
• W2092360041 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7130276" @default.
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