FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092370766> ?p ?o ?g. }

• W2092370766 endingPage "1025" @default.
• W2092370766 startingPage "1022" @default.
• W2092370766 abstract "TRPM5, a cation channel of the TRP superfamily, is highly expressed in taste buds of the tongue, where it has a key role in the perception of sweet, umami and bitter tastes. Activation of TRPM5 occurs downstream of the activation of G-protein-coupled taste receptors and is proposed to generate a depolarizing potential in the taste receptor cells. Factors that modulate TRPM5 activity are therefore expected to influence taste. Here we show that TRPM5 is a highly temperature-sensitive, heat-activated channel: inward TRPM5 currents increase steeply at temperatures between 15 and 35 degrees C. TRPM4, a close homologue of TRPM5, shows similar temperature sensitivity. Heat activation is due to a temperature-dependent shift of the activation curve, in analogy to other thermosensitive TRP channels. Moreover, we show that increasing temperature between 15 and 35 degrees C markedly enhances the gustatory nerve response to sweet compounds in wild-type but not in Trpm5 knockout mice. The strong temperature sensitivity of TRPM5 may underlie known effects of temperature on perceived taste in humans, including enhanced sweetness perception at high temperatures and 'thermal taste', the phenomenon whereby heating or cooling of the tongue evoke sensations of taste in the absence of tastants." @default.
• W2092370766 created "2016-06-24" @default.
• W2092370766 creator A5006920818 @default.
• W2092370766 creator A5010211984 @default.
• W2092370766 creator A5012891699 @default.
• W2092370766 creator A5021952303 @default.
• W2092370766 creator A5053465320 @default.
• W2092370766 creator A5054894206 @default.
• W2092370766 creator A5071455949 @default.
• W2092370766 creator A5087089940 @default.
• W2092370766 date "2005-12-01" @default.
• W2092370766 modified "2023-10-08" @default.
• W2092370766 title "Heat activation of TRPM5 underlies thermal sensitivity of sweet taste" @default.
• W2092370766 cites W1562645017 @default.
• W2092370766 cites W1585173856 @default.
• W2092370766 cites W1973418226 @default.
• W2092370766 cites W1974058597 @default.
• W2092370766 cites W1980092005 @default.
• W2092370766 cites W1983615879 @default.
• W2092370766 cites W2040471411 @default.
• W2092370766 cites W2040664792 @default.
• W2092370766 cites W2063502459 @default.
• W2092370766 cites W2065897367 @default.
• W2092370766 cites W2086339199 @default.
• W2092370766 cites W2090617423 @default.
• W2092370766 cites W2096200782 @default.
• W2092370766 cites W2106366826 @default.
• W2092370766 cites W2111298485 @default.
• W2092370766 cites W2111730001 @default.
• W2092370766 cites W2121570525 @default.
• W2092370766 cites W2153646267 @default.
• W2092370766 cites W2169891816 @default.
• W2092370766 cites W4241897948 @default.
• W2092370766 doi "https://doi.org/10.1038/nature04248" @default.
• W2092370766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16355226" @default.
• W2092370766 hasPublicationYear "2005" @default.
• W2092370766 type Work @default.
• W2092370766 sameAs 2092370766 @default.
• W2092370766 citedByCount "413" @default.
• W2092370766 countsByYear W20923707662012 @default.
• W2092370766 countsByYear W20923707662013 @default.
• W2092370766 countsByYear W20923707662014 @default.
• W2092370766 countsByYear W20923707662015 @default.
• W2092370766 countsByYear W20923707662016 @default.
• W2092370766 countsByYear W20923707662017 @default.
• W2092370766 countsByYear W20923707662018 @default.
• W2092370766 countsByYear W20923707662019 @default.
• W2092370766 countsByYear W20923707662020 @default.
• W2092370766 countsByYear W20923707662021 @default.
• W2092370766 countsByYear W20923707662022 @default.
• W2092370766 countsByYear W20923707662023 @default.
• W2092370766 crossrefType "journal-article" @default.
• W2092370766 hasAuthorship W2092370766A5006920818 @default.
• W2092370766 hasAuthorship W2092370766A5010211984 @default.
• W2092370766 hasAuthorship W2092370766A5012891699 @default.
• W2092370766 hasAuthorship W2092370766A5021952303 @default.
• W2092370766 hasAuthorship W2092370766A5053465320 @default.
• W2092370766 hasAuthorship W2092370766A5054894206 @default.
• W2092370766 hasAuthorship W2092370766A5071455949 @default.
• W2092370766 hasAuthorship W2092370766A5087089940 @default.
• W2092370766 hasBestOaLocation W20923707662 @default.
• W2092370766 hasConcept C12554922 @default.
• W2092370766 hasConcept C142724271 @default.
• W2092370766 hasConcept C155164980 @default.
• W2092370766 hasConcept C170493617 @default.
• W2092370766 hasConcept C178006227 @default.
• W2092370766 hasConcept C185592680 @default.
• W2092370766 hasConcept C2776946002 @default.
• W2092370766 hasConcept C2779476700 @default.
• W2092370766 hasConcept C2779744641 @default.
• W2092370766 hasConcept C31903555 @default.
• W2092370766 hasConcept C4141045 @default.
• W2092370766 hasConcept C55493867 @default.
• W2092370766 hasConcept C71924100 @default.
• W2092370766 hasConcept C86803240 @default.
• W2092370766 hasConcept C8868529 @default.
• W2092370766 hasConceptScore W2092370766C12554922 @default.
• W2092370766 hasConceptScore W2092370766C142724271 @default.
• W2092370766 hasConceptScore W2092370766C155164980 @default.
• W2092370766 hasConceptScore W2092370766C170493617 @default.
• W2092370766 hasConceptScore W2092370766C178006227 @default.
• W2092370766 hasConceptScore W2092370766C185592680 @default.
• W2092370766 hasConceptScore W2092370766C2776946002 @default.
• W2092370766 hasConceptScore W2092370766C2779476700 @default.
• W2092370766 hasConceptScore W2092370766C2779744641 @default.
• W2092370766 hasConceptScore W2092370766C31903555 @default.
• W2092370766 hasConceptScore W2092370766C4141045 @default.
• W2092370766 hasConceptScore W2092370766C55493867 @default.
• W2092370766 hasConceptScore W2092370766C71924100 @default.
• W2092370766 hasConceptScore W2092370766C86803240 @default.
• W2092370766 hasConceptScore W2092370766C8868529 @default.
• W2092370766 hasIssue "7070" @default.
• W2092370766 hasLocation W20923707661 @default.
• W2092370766 hasLocation W20923707662 @default.
• W2092370766 hasLocation W20923707663 @default.
• W2092370766 hasOpenAccess W2092370766 @default.
• W2092370766 hasPrimaryLocation W20923707661 @default.
• W2092370766 hasRelatedWork W1981905726 @default.

• next