Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092371739> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W2092371739 abstract "5'-deoxy-5-fluorouridine (5'-DFUR) and capecitabine are oral anti-cancer agents, which are enzymatically converted to 5-fluorouracil (5-FU) by thymidine phosphorylase in humans and uridine phosphorylase in mice. Since the activity of these phosphorylases is higher in cancerous tissue than in normal tissue, systemic administration of 5'-DFUR and capecitabine achieves high intratumoral 5-FU levels and low adverse effects on non-tumoral tissue. Accordingly, 5'-DFUR and capecitabine are widely used for the treatment of cancer patients. In the present study, we examined the effects of 5'-DFUR and capecitabine on bone metastases, one of the most common complications of breast cancer, using an animal model in which inoculation of 4T1/luc mouse breast cancer cells into the mammary fat pads of female BALB/c mice developed spontaneous metastases in distant organs including bone, lung and liver. Mice received 4T1/luc cell inoculation in the mammary fat pad at day 0 and oral 5'-DFUR (31, 62, 123 or 246 mg/kg) or capecitabine (90, 180 or 359 mg/kg) daily from day 7 to day 21. Both 5'-DFUR and capecitabine significantly inhibited orthotopic tumor formation and distant metastases to bone, lung and liver in a dose-dependent manner. Of note, the lowest dose of 5'-DFUR (31 mg/kg) and capecitabine (90 mg/kg), which failed to inhibit orthotopic tumor development and the lung and liver metastases, significantly reduced the bone metastases. In conclusion, our results suggest that oral 5'-DFUR and capecitabine are effective for the treatment of primary and secondary breast tumors. Most notably, they also suggest that these agents are preferentially beneficial for bone metastases." @default.
- W2092371739 created "2016-06-24" @default.
- W2092371739 creator A5028445962 @default.
- W2092371739 creator A5032547230 @default.
- W2092371739 creator A5044650735 @default.
- W2092371739 creator A5050497319 @default.
- W2092371739 creator A5077043379 @default.
- W2092371739 creator A5081469161 @default.
- W2092371739 creator A5086021529 @default.
- W2092371739 date "2005-09-01" @default.
- W2092371739 modified "2023-09-25" @default.
- W2092371739 title "Preferential inhibition of bone metastases by 5'-deoxy-5-fluorouridine and capecitabine in the 4T1/luc mouse breast cancer model" @default.
- W2092371739 doi "https://doi.org/10.3892/or.14.3.695" @default.
- W2092371739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16077977" @default.
- W2092371739 hasPublicationYear "2005" @default.
- W2092371739 type Work @default.
- W2092371739 sameAs 2092371739 @default.
- W2092371739 citedByCount "4" @default.
- W2092371739 countsByYear W20923717392014 @default.
- W2092371739 countsByYear W20923717392018 @default.
- W2092371739 crossrefType "journal-article" @default.
- W2092371739 hasAuthorship W2092371739A5028445962 @default.
- W2092371739 hasAuthorship W2092371739A5032547230 @default.
- W2092371739 hasAuthorship W2092371739A5044650735 @default.
- W2092371739 hasAuthorship W2092371739A5050497319 @default.
- W2092371739 hasAuthorship W2092371739A5077043379 @default.
- W2092371739 hasAuthorship W2092371739A5081469161 @default.
- W2092371739 hasAuthorship W2092371739A5086021529 @default.
- W2092371739 hasConcept C121608353 @default.
- W2092371739 hasConcept C126322002 @default.
- W2092371739 hasConcept C2776735402 @default.
- W2092371739 hasConcept C2777909004 @default.
- W2092371739 hasConcept C2780456651 @default.
- W2092371739 hasConcept C502942594 @default.
- W2092371739 hasConcept C526805850 @default.
- W2092371739 hasConcept C530470458 @default.
- W2092371739 hasConcept C71924100 @default.
- W2092371739 hasConceptScore W2092371739C121608353 @default.
- W2092371739 hasConceptScore W2092371739C126322002 @default.
- W2092371739 hasConceptScore W2092371739C2776735402 @default.
- W2092371739 hasConceptScore W2092371739C2777909004 @default.
- W2092371739 hasConceptScore W2092371739C2780456651 @default.
- W2092371739 hasConceptScore W2092371739C502942594 @default.
- W2092371739 hasConceptScore W2092371739C526805850 @default.
- W2092371739 hasConceptScore W2092371739C530470458 @default.
- W2092371739 hasConceptScore W2092371739C71924100 @default.
- W2092371739 hasLocation W20923717391 @default.
- W2092371739 hasLocation W20923717392 @default.
- W2092371739 hasOpenAccess W2092371739 @default.
- W2092371739 hasPrimaryLocation W20923717391 @default.
- W2092371739 hasRelatedWork W1840414876 @default.
- W2092371739 hasRelatedWork W1971345605 @default.
- W2092371739 hasRelatedWork W1994378934 @default.
- W2092371739 hasRelatedWork W2005850646 @default.
- W2092371739 hasRelatedWork W2038807201 @default.
- W2092371739 hasRelatedWork W2102433244 @default.
- W2092371739 hasRelatedWork W2103221219 @default.
- W2092371739 hasRelatedWork W2469661112 @default.
- W2092371739 hasRelatedWork W2589892503 @default.
- W2092371739 hasRelatedWork W4205345090 @default.
- W2092371739 isParatext "false" @default.
- W2092371739 isRetracted "false" @default.
- W2092371739 magId "2092371739" @default.
- W2092371739 workType "article" @default.