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- W2092381256 abstract "Abstract The turnover of 125 I- or 131 I-labelled low density apolipoprotein (apoLDL) has been measured in two putative homozygotes with familial hypercholesterolaemia and one control subject after plasma exchange. One patient, with a IIa lipoprotein pattern, had a markedly reduced fractional catabolic rate over a wide range of cholesterol concentration and a moderate increase in synthesis of apoLDL, whereas the other patient, with a IIb pattern, had a normal or slightly subnormal fractional catabolic rate but a very marked increase in apoLDL synthesis. Combined therapy with cholestyramine and clofibrate increased the fractional catabolic rate and decreased the synthesis of apoLDL in both patients. These findings suggest that both decreased catabolism and increased synthesis of apoLDL occur in homozygous familial hypercholesterolaemia, but to a different extent in individual patients." @default.
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- W2092381256 date "1976-03-01" @default.
- W2092381256 modified "2023-10-14" @default.
- W2092381256 title "Low density lipoprotein turnover in familial hypercholesterolaemia after plasma exchange" @default.
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- W2092381256 doi "https://doi.org/10.1016/0021-9150(76)90112-x" @default.
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