FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092412131> ?p ?o ?g. }

• W2092412131 endingPage "2332" @default.
• W2092412131 startingPage "2323" @default.
• W2092412131 abstract "Abstract Adiponectin (APN), a cytokine constitutively produced in fat tissue, has been shown to exert anti‐inflammatory effects in various disease models. While the influence of APN on monocytic cells has been extensively studied in vitro, little is known about its role in T cells. In this study, we show that while <10% of human peripheral blood T cells express adiponectin receptors (AdipoRs) on their surface, most T cells store AdipoRs in intracellular compartments. AdipoRs colocalized with immune regulatory molecules CTLA‐4 and TIRC7 within clathrin‐coated vesicles. After stimulation, the expression of adiponectin receptor 1 (AdipoR1) and AdipoR2 was upregulated on the surface of antigen‐specific T cells, as determined by tetramer or CD137 staining, and AdipoR1 and AdipoR2 coexpressed with CTLA‐4. Addition of APN resulted in a significant diminution of antigen‐specific T‐cell expansion. Mechanistically, APN enhanced apoptosis and inhibited proliferation of antigen‐specific T‐cell lines. Further, APN directly inhibited cytokine production in response to antigen stimulation. In line with the in vitro data, APN‐deficient (knockout, KO) mice had higher frequencies of CD137 + T cells upon Coxsackie B virus infection. Altogether, our data suggest that APN is a novel negative T‐cell regulator. In contrast to the CTLA‐4 ligand B7 only expressed on APCs, APN is abundant in human plasma." @default.
• W2092412131 created "2016-06-24" @default.
• W2092412131 creator A5000953117 @default.
• W2092412131 creator A5009341329 @default.
• W2092412131 creator A5009665482 @default.
• W2092412131 creator A5016773223 @default.
• W2092412131 creator A5032919938 @default.
• W2092412131 creator A5049060150 @default.
• W2092412131 creator A5049131624 @default.
• W2092412131 creator A5056857657 @default.
• W2092412131 creator A5064595793 @default.
• W2092412131 creator A5070481872 @default.
• W2092412131 creator A5074892730 @default.
• W2092412131 creator A5076630199 @default.
• W2092412131 creator A5088622402 @default.
• W2092412131 creator A5089758540 @default.
• W2092412131 date "2011-06-06" @default.
• W2092412131 modified "2023-10-18" @default.
• W2092412131 title "Adiponectin is a negative regulator of antigen-activated T cells" @default.
• W2092412131 cites W1501768842 @default.
• W2092412131 cites W1557391093 @default.
• W2092412131 cites W1562891630 @default.
• W2092412131 cites W1965063742 @default.
• W2092412131 cites W1965830486 @default.
• W2092412131 cites W1970851689 @default.
• W2092412131 cites W1982596194 @default.
• W2092412131 cites W1984536659 @default.
• W2092412131 cites W1985278235 @default.
• W2092412131 cites W1987963517 @default.
• W2092412131 cites W1997978122 @default.
• W2092412131 cites W2000265203 @default.
• W2092412131 cites W2000794212 @default.
• W2092412131 cites W2005505978 @default.
• W2092412131 cites W2011591230 @default.
• W2092412131 cites W2022201010 @default.
• W2092412131 cites W2048073154 @default.
• W2092412131 cites W2053911884 @default.
• W2092412131 cites W2074014179 @default.
• W2092412131 cites W2084553046 @default.
• W2092412131 cites W2088079762 @default.
• W2092412131 cites W2089323191 @default.
• W2092412131 cites W2094991897 @default.
• W2092412131 cites W2095580512 @default.
• W2092412131 cites W2112377527 @default.
• W2092412131 cites W2115786206 @default.
• W2092412131 cites W2122322331 @default.
• W2092412131 cites W2125173371 @default.
• W2092412131 cites W2130064617 @default.
• W2092412131 cites W2134100055 @default.
• W2092412131 cites W2142498139 @default.
• W2092412131 cites W2146444493 @default.
• W2092412131 cites W2148204112 @default.
• W2092412131 cites W2169034744 @default.
• W2092412131 doi "https://doi.org/10.1002/eji.201041349" @default.
• W2092412131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21538348" @default.
• W2092412131 hasPublicationYear "2011" @default.
• W2092412131 type Work @default.
• W2092412131 sameAs 2092412131 @default.
• W2092412131 citedByCount "91" @default.
• W2092412131 countsByYear W20924121312012 @default.
• W2092412131 countsByYear W20924121312013 @default.
• W2092412131 countsByYear W20924121312014 @default.
• W2092412131 countsByYear W20924121312015 @default.
• W2092412131 countsByYear W20924121312016 @default.
• W2092412131 countsByYear W20924121312017 @default.
• W2092412131 countsByYear W20924121312018 @default.
• W2092412131 countsByYear W20924121312019 @default.
• W2092412131 countsByYear W20924121312020 @default.
• W2092412131 countsByYear W20924121312021 @default.
• W2092412131 countsByYear W20924121312022 @default.
• W2092412131 countsByYear W20924121312023 @default.
• W2092412131 crossrefType "journal-article" @default.
• W2092412131 hasAuthorship W2092412131A5000953117 @default.
• W2092412131 hasAuthorship W2092412131A5009341329 @default.
• W2092412131 hasAuthorship W2092412131A5009665482 @default.
• W2092412131 hasAuthorship W2092412131A5016773223 @default.
• W2092412131 hasAuthorship W2092412131A5032919938 @default.
• W2092412131 hasAuthorship W2092412131A5049060150 @default.
• W2092412131 hasAuthorship W2092412131A5049131624 @default.
• W2092412131 hasAuthorship W2092412131A5056857657 @default.
• W2092412131 hasAuthorship W2092412131A5064595793 @default.
• W2092412131 hasAuthorship W2092412131A5070481872 @default.
• W2092412131 hasAuthorship W2092412131A5074892730 @default.
• W2092412131 hasAuthorship W2092412131A5076630199 @default.
• W2092412131 hasAuthorship W2092412131A5088622402 @default.
• W2092412131 hasAuthorship W2092412131A5089758540 @default.
• W2092412131 hasBestOaLocation W20924121311 @default.
• W2092412131 hasConcept C134018914 @default.
• W2092412131 hasConcept C147483822 @default.
• W2092412131 hasConcept C153911025 @default.
• W2092412131 hasConcept C154317977 @default.
• W2092412131 hasConcept C202751555 @default.
• W2092412131 hasConcept C203014093 @default.
• W2092412131 hasConcept C2776090121 @default.
• W2092412131 hasConcept C2776782570 @default.
• W2092412131 hasConcept C2777391703 @default.
• W2092412131 hasConcept C2778690821 @default.
• W2092412131 hasConcept C2779306644 @default.

• next