Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092413426> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2092413426 abstract "PG545 is Progen9s lead oncology candidate currently undergoing formal preclinical development. PG545 is a synthetic heparan sulfate (HS) mimetic that prevents neovascularization by inhibiting growth‐factor heparan sulfate binding and metastasis through the inhibition of heparan sulfate cleavage by heparanase. PG545 was assessed for efficacy in a number of xenograft models, namely the MDA‐MB‐231 (breast), PC3 (prostate), HepG2 (liver) and the orthotopic model Hep3B (liver). In the Hep3B liver cancer model, a concurrent study dosed tumor‐bearing mice with radiolabeled PG545 every 96 h for three doses in order to generate a pharmacokinetic (PK) profile of the compound in blood and tumor tissue. In the efficacy studies, once or twice weekly treatment was initiated once the tumors reached 100–200cm3 (depending on the study). Although not significantly different to twice weekly dosing, PG545 exhibited maximal antitumor efficacy when dosed once weekly in each of the four independent studies. Moreover, in the Hep3B liver cancer study, PG545 exhibited antitumor activity to a similar extent as the tyrosine kinase inhibitor sorafenib which is approved by the FDA for inoperable hepatocellular carcinoma. A preliminary pharmacokinetic profile using radiolabeled compound [3H]‐PG545 was also obtained. Data generated using both compartmental and non‐compartmental modeling indicate a favourable pharmacokinetic profile and significant uptake of [3H]‐PG545 into the tumor from the bloodstream. Taken together, the tumor efficacy and pharmacokinetic data support the ongoing preclinical development of PG545 as a once weekly, subcutaneously administered injection for the treatment of cancer. Citation Information: Mol Cancer Ther 2009;8(12 Suppl):A17." @default.
- W2092413426 created "2016-06-24" @default.
- W2092413426 creator A5003810137 @default.
- W2092413426 creator A5029324255 @default.
- W2092413426 creator A5058544571 @default.
- W2092413426 creator A5061208744 @default.
- W2092413426 creator A5069222865 @default.
- W2092413426 creator A5069308257 @default.
- W2092413426 creator A5076782260 @default.
- W2092413426 creator A5083803543 @default.
- W2092413426 date "2009-12-10" @default.
- W2092413426 modified "2023-09-25" @default.
- W2092413426 title "Abstract A17: The dual angiogenesis/heparanase inhibitor PG545 inhibits solid tumor progression in models of breast, prostate and liver cancer: A comparative assessment of once versus twice weekly administration schedules" @default.
- W2092413426 doi "https://doi.org/10.1158/1535-7163.targ-09-a17" @default.
- W2092413426 hasPublicationYear "2009" @default.
- W2092413426 type Work @default.
- W2092413426 sameAs 2092413426 @default.
- W2092413426 citedByCount "3" @default.
- W2092413426 countsByYear W20924134262012 @default.
- W2092413426 crossrefType "proceedings-article" @default.
- W2092413426 hasAuthorship W2092413426A5003810137 @default.
- W2092413426 hasAuthorship W2092413426A5029324255 @default.
- W2092413426 hasAuthorship W2092413426A5058544571 @default.
- W2092413426 hasAuthorship W2092413426A5061208744 @default.
- W2092413426 hasAuthorship W2092413426A5069222865 @default.
- W2092413426 hasAuthorship W2092413426A5069308257 @default.
- W2092413426 hasAuthorship W2092413426A5076782260 @default.
- W2092413426 hasAuthorship W2092413426A5083803543 @default.
- W2092413426 hasConcept C112705442 @default.
- W2092413426 hasConcept C121608353 @default.
- W2092413426 hasConcept C126322002 @default.
- W2092413426 hasConcept C2776056115 @default.
- W2092413426 hasConcept C2776231280 @default.
- W2092413426 hasConcept C2777478136 @default.
- W2092413426 hasConcept C2777557582 @default.
- W2092413426 hasConcept C2778019345 @default.
- W2092413426 hasConcept C2778041096 @default.
- W2092413426 hasConcept C2778695046 @default.
- W2092413426 hasConcept C2779013556 @default.
- W2092413426 hasConcept C2780192828 @default.
- W2092413426 hasConcept C2780394083 @default.
- W2092413426 hasConcept C502942594 @default.
- W2092413426 hasConcept C71924100 @default.
- W2092413426 hasConcept C98274493 @default.
- W2092413426 hasConceptScore W2092413426C112705442 @default.
- W2092413426 hasConceptScore W2092413426C121608353 @default.
- W2092413426 hasConceptScore W2092413426C126322002 @default.
- W2092413426 hasConceptScore W2092413426C2776056115 @default.
- W2092413426 hasConceptScore W2092413426C2776231280 @default.
- W2092413426 hasConceptScore W2092413426C2777478136 @default.
- W2092413426 hasConceptScore W2092413426C2777557582 @default.
- W2092413426 hasConceptScore W2092413426C2778019345 @default.
- W2092413426 hasConceptScore W2092413426C2778041096 @default.
- W2092413426 hasConceptScore W2092413426C2778695046 @default.
- W2092413426 hasConceptScore W2092413426C2779013556 @default.
- W2092413426 hasConceptScore W2092413426C2780192828 @default.
- W2092413426 hasConceptScore W2092413426C2780394083 @default.
- W2092413426 hasConceptScore W2092413426C502942594 @default.
- W2092413426 hasConceptScore W2092413426C71924100 @default.
- W2092413426 hasConceptScore W2092413426C98274493 @default.
- W2092413426 hasLocation W20924134261 @default.
- W2092413426 hasOpenAccess W2092413426 @default.
- W2092413426 hasPrimaryLocation W20924134261 @default.
- W2092413426 hasRelatedWork W1858146128 @default.
- W2092413426 hasRelatedWork W1981841536 @default.
- W2092413426 hasRelatedWork W2005205470 @default.
- W2092413426 hasRelatedWork W2021534537 @default.
- W2092413426 hasRelatedWork W2056402723 @default.
- W2092413426 hasRelatedWork W2077893649 @default.
- W2092413426 hasRelatedWork W2090162658 @default.
- W2092413426 hasRelatedWork W2101433461 @default.
- W2092413426 hasRelatedWork W2118908256 @default.
- W2092413426 hasRelatedWork W2119596897 @default.
- W2092413426 hasRelatedWork W2121805411 @default.
- W2092413426 hasRelatedWork W2304149114 @default.
- W2092413426 hasRelatedWork W2323389891 @default.
- W2092413426 hasRelatedWork W2326028600 @default.
- W2092413426 hasRelatedWork W2403978378 @default.
- W2092413426 hasRelatedWork W2562536166 @default.
- W2092413426 hasRelatedWork W2562629092 @default.
- W2092413426 hasRelatedWork W2739968211 @default.
- W2092413426 hasRelatedWork W3161490956 @default.
- W2092413426 hasRelatedWork W3181380383 @default.
- W2092413426 isParatext "false" @default.
- W2092413426 isRetracted "false" @default.
- W2092413426 magId "2092413426" @default.
- W2092413426 workType "article" @default.