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- W2092418847 abstract "The central nervous system stimulants caffeine and centedrin increase the γ-aminobutyric acid content of the brain by 25–30 per cent. Administration of andaxin, which caused a general depression, results in a 23 per cent decrease in the brain γ-aminobutyric acid level. Intraperitoneal injection in rats of picrotoxin, metrazol, caffeine, centedrin, hept-amyi, 20–28 M.D., barbamil and andaxin does not produce changes in the enzymatic activities of l-glutamic acid decarboxylase and γ-aminobutyric acid-α-ketoglutaric acid transaminase. Addition of these pharmacological preparations to the incubation mixture of brain homogenates of rats also does not alter the activity of the enzyme systems connected with γ-aminobutyric acid in the brain. Administration in vitro of caffeine (600 mg/100 g brain tissue) suppressed l-glutamic acid decarboxylase by about 10 per cent." @default.
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- W2092418847 date "1966-01-01" @default.
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- W2092418847 title "Effect of certain drugs on the γ-aminobutyric acid system of the central nervous system" @default.
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- W2092418847 doi "https://doi.org/10.1016/0006-2952(66)90109-2" @default.
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