FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092437474> ?p ?o ?g. }

• W2092437474 endingPage "902" @default.
• W2092437474 startingPage "897" @default.
• W2092437474 abstract "To understand the mechanism by which phorbol esters (PMA) stimulate c-jun transcription In human leukemic cell line U937, we have mutated specific enhancer sequences within the c-jun promoter. We find in the region of DNA from −132 to +170 containing Sp1, C-TF and AP-1 sequences that mutation of the AP-1 sequence alone is not sufficient to abrogate transcription, and mutation of the Sp1 sequence Increases transcription 4-fold. Although mutation of the CTF site had no effect, CTF and AP-1 mutations together totally abrogate PMA-induced transcription. In comparison mutations of either of these sites alone or together in a construct containing −1639/ + 740 of the c-jun promoter had no effect on transcription. Because this data suggested the possibility of other upstream control regions, we sequenced the promoter from −142 to −1639. This sequence demonstrates a greater than 70% homology between human, and mouse c-jun promoters for the region from −142 to −441, and a second AP-1-like site In the −183 to −192 region. Mutation of this site did not influence transcription by PMA. By making constructs containing varying portions of the promoter, we have identified the region between −142 and − 711 to be responsible for mediating PMA-induced c-jun transcription." @default.
• W2092437474 created "2016-06-24" @default.
• W2092437474 creator A5009879531 @default.
• W2092437474 creator A5016452935 @default.
• W2092437474 creator A5073411167 @default.
• W2092437474 creator A5086393033 @default.
• W2092437474 date "1992-01-01" @default.
• W2092437474 modified "2023-09-27" @default.
• W2092437474 title "Upstream regions of the<i>c-jun</i>promoter regulate phorbol ester-induced transcription in U937 leukemic cells" @default.
• W2092437474 cites W1504962298 @default.
• W2092437474 cites W1513355409 @default.
• W2092437474 cites W1581718250 @default.
• W2092437474 cites W1589819858 @default.
• W2092437474 cites W1597893467 @default.
• W2092437474 cites W1916260177 @default.
• W2092437474 cites W1964831845 @default.
• W2092437474 cites W1967004332 @default.
• W2092437474 cites W1973005880 @default.
• W2092437474 cites W1976906198 @default.
• W2092437474 cites W1983512144 @default.
• W2092437474 cites W1987897953 @default.
• W2092437474 cites W1995646607 @default.
• W2092437474 cites W1999689481 @default.
• W2092437474 cites W2003411699 @default.
• W2092437474 cites W2003893812 @default.
• W2092437474 cites W2012883868 @default.
• W2092437474 cites W2025723633 @default.
• W2092437474 cites W2037824747 @default.
• W2092437474 cites W2058215940 @default.
• W2092437474 cites W2058901530 @default.
• W2092437474 cites W2064089886 @default.
• W2092437474 cites W2077528944 @default.
• W2092437474 cites W2081135713 @default.
• W2092437474 cites W2083869788 @default.
• W2092437474 cites W2085087848 @default.
• W2092437474 cites W2085585711 @default.
• W2092437474 cites W2094872845 @default.
• W2092437474 cites W2122734844 @default.
• W2092437474 cites W2124551132 @default.
• W2092437474 cites W2125535264 @default.
• W2092437474 cites W2125861481 @default.
• W2092437474 cites W2136536126 @default.
• W2092437474 cites W2155659061 @default.
• W2092437474 cites W2419482644 @default.
• W2092437474 cites W2461415929 @default.
• W2092437474 cites W69763153 @default.
• W2092437474 cites W78317913 @default.
• W2092437474 doi "https://doi.org/10.1093/nar/20.4.897" @default.
• W2092437474 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/312034" @default.
• W2092437474 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1542579" @default.
• W2092437474 hasPublicationYear "1992" @default.
• W2092437474 type Work @default.
• W2092437474 sameAs 2092437474 @default.
• W2092437474 citedByCount "32" @default.
• W2092437474 countsByYear W20924374742014 @default.
• W2092437474 countsByYear W20924374742021 @default.
• W2092437474 crossrefType "journal-article" @default.
• W2092437474 hasAuthorship W2092437474A5009879531 @default.
• W2092437474 hasAuthorship W2092437474A5016452935 @default.
• W2092437474 hasAuthorship W2092437474A5073411167 @default.
• W2092437474 hasAuthorship W2092437474A5086393033 @default.
• W2092437474 hasBestOaLocation W20924374742 @default.
• W2092437474 hasConcept C101762097 @default.
• W2092437474 hasConcept C104317684 @default.
• W2092437474 hasConcept C111936080 @default.
• W2092437474 hasConcept C132376346 @default.
• W2092437474 hasConcept C138885662 @default.
• W2092437474 hasConcept C150194340 @default.
• W2092437474 hasConcept C153911025 @default.
• W2092437474 hasConcept C179926584 @default.
• W2092437474 hasConcept C192245184 @default.
• W2092437474 hasConcept C41895202 @default.
• W2092437474 hasConcept C54355233 @default.
• W2092437474 hasConcept C552990157 @default.
• W2092437474 hasConcept C76753757 @default.
• W2092437474 hasConcept C86339819 @default.
• W2092437474 hasConcept C86803240 @default.
• W2092437474 hasConceptScore W2092437474C101762097 @default.
• W2092437474 hasConceptScore W2092437474C104317684 @default.
• W2092437474 hasConceptScore W2092437474C111936080 @default.
• W2092437474 hasConceptScore W2092437474C132376346 @default.
• W2092437474 hasConceptScore W2092437474C138885662 @default.
• W2092437474 hasConceptScore W2092437474C150194340 @default.
• W2092437474 hasConceptScore W2092437474C153911025 @default.
• W2092437474 hasConceptScore W2092437474C179926584 @default.
• W2092437474 hasConceptScore W2092437474C192245184 @default.
• W2092437474 hasConceptScore W2092437474C41895202 @default.
• W2092437474 hasConceptScore W2092437474C54355233 @default.
• W2092437474 hasConceptScore W2092437474C552990157 @default.
• W2092437474 hasConceptScore W2092437474C76753757 @default.
• W2092437474 hasConceptScore W2092437474C86339819 @default.
• W2092437474 hasConceptScore W2092437474C86803240 @default.
• W2092437474 hasIssue "4" @default.
• W2092437474 hasLocation W20924374741 @default.
• W2092437474 hasLocation W20924374742 @default.
• W2092437474 hasLocation W20924374743 @default.
• W2092437474 hasLocation W20924374744 @default.
• W2092437474 hasOpenAccess W2092437474 @default.

• next