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• W2092440285 abstract "Growth hormone (GH) secretion in salmonids and other fish is under the control of a number of hypothalamic factors, but negative feed-back regulation by circulating hormones can also be of importance for the regulation of GH secretion. Mammalian studies show that GH has a negative feed-back effect on its own secretion. In order to elucidate if GH levels present a direct ultra-short negative feedback loop at the pituitary level GH secretion was studied in intact pituitaries from 50 g fish in an in vitro perifusion system. Following an initial equilibrium period pituitaries were exposed to five increasing concentrations (1-1,000 ng ml(-1)) of ovine GH (oGH) in 20-min steps, before being returned to a GH-free perifusion. Ovine GH caused a significant dose-dependent inhibition of GH secretion and it is concluded that GH can exert a direct negative feedback control on GH secretion at the pituitary level." @default.
• W2092440285 created "2016-06-24" @default.
• W2092440285 creator A5040379284 @default.
• W2092440285 creator A5088307108 @default.
• W2092440285 date "2000-07-01" @default.
• W2092440285 modified "2023-09-25" @default.
• W2092440285 title "Growth hormone inhibits growth hormone secretion from the rainbow trout pituitary in vitro" @default.
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• W2092440285 doi "https://doi.org/10.1016/s0742-8413(00)00120-1" @default.
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