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• W2092441650 endingPage "1294" @default.
• W2092441650 startingPage "1284" @default.
• W2092441650 abstract "Structural changes of barnase during folding were investigated using time-resolved small-angle X-ray scattering (SAXS). The folding of barnase involves a burst-phase intermediate, sometimes designated as the denatured state under physiological conditions, D(phys), and a second hidden intermediate. Equilibrium SAXS measurements showed that the radius of gyration (R(g)) of the guanidine unfolded state (U) is 26.9±0.7 Å, which remains largely constant over a wide denaturant concentration range. Time-resolved SAXS measurements showed that the R(g) value extrapolated from kinetic R(g) data to time zero, R(g,0), is 24.3±0.1 Å, which is smaller than that of U but which is expanded from that of folding intermediates of other proteins with similar chain lengths (19 Å). After the burst-phase change, a single-exponential reduction in R(g)(2) was observed, which corresponds to the formation of the native state for the major component containing the native trans proline isomer. We estimated R(g) of the minor component of D(phys) containing the non-native cis proline isomer (D(phys,cis)) to be 25.7±0.6 Å. Moreover, R(g) of the major component of D(phys) containing the native proline isomer (D(phys,tra)) was estimated as 23.9±0.2 Å based on R(g,0). Consequently, both components of the burst-phase intermediate of barnase (D(phys,tra) and D(phys,cis)) are still largely expanded. It was inferred that D(phys) possesses the N-terminal helix and the center of the β-sheet formed independently and that the formation of the remainder of the protein occurs in the slower phase." @default.
• W2092441650 created "2016-06-24" @default.
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• W2092441650 date "2011-02-01" @default.
• W2092441650 modified "2023-10-16" @default.
• W2092441650 title "Time-Resolved Small-Angle X-ray Scattering Study of the Folding Dynamics of Barnase" @default.
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• W2092441650 doi "https://doi.org/10.1016/j.jmb.2010.11.052" @default.
• W2092441650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21146541" @default.
• W2092441650 hasPublicationYear "2011" @default.
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