Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092446204> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2092446204 abstract "Flestolol (ACC-9089) is a nonselective, competitive, ultra-short-acting beta-adrenergic blocking agent, without any intrinsic sympathomimetic activity. Flestolol is metabolized by plasma esterases and has an elimination half-life of approximately 6.5 minutes. This agent was well tolerated in healthy volunteers at doses up to 100 micrograms/kg/min. In long-term infusion studies, flestolol was well tolerated at the effective beta-blocking dose (5 micrograms/kg/min) for up to seven days. Flestolol blood concentrations increased linearly with increasing dose and good correlation exists between blood concentrations of flestolol and beta-adrenergic blockade. Flestolol produced a dose-dependent attenuation of isoproterenol-induced tachycardia. Electrophysiologic and hemodynamic effects of flestolol are similar to those of other beta blockers. In contrast with other beta blockers, flestolol-induced effects reverse rapidly (within 30 minutes) following discontinuation because of its short half-life. Flestolol effectively reduced heart rate in patients with supraventricular tachyarrhythmia. In patients with unstable angina, flestolol infusion was found to be safe and effective in controlling chest pain. It is concluded that flestolol is a potent, well-tolerated, ultra-short-acting beta-adrenergic blocking agent. Use of flestolol in the critical care setting is currently undergoing investigation." @default.
- W2092446204 created "2016-06-24" @default.
- W2092446204 creator A5034523412 @default.
- W2092446204 creator A5064117907 @default.
- W2092446204 creator A5072150282 @default.
- W2092446204 creator A5060928089 @default.
- W2092446204 date "1986-03-01" @default.
- W2092446204 modified "2023-10-09" @default.
- W2092446204 title "Flestolol: An Ultra‐short‐Acting Beta‐Adrenergic Blocking Agent" @default.
- W2092446204 cites W1980496646 @default.
- W2092446204 cites W2020141263 @default.
- W2092446204 cites W2025488693 @default.
- W2092446204 cites W2027885466 @default.
- W2092446204 cites W2051983688 @default.
- W2092446204 cites W2055076608 @default.
- W2092446204 cites W2079519156 @default.
- W2092446204 cites W2084628587 @default.
- W2092446204 cites W2120628703 @default.
- W2092446204 doi "https://doi.org/10.1002/j.1552-4604.1986.tb02986.x" @default.
- W2092446204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2870085" @default.
- W2092446204 hasPublicationYear "1986" @default.
- W2092446204 type Work @default.
- W2092446204 sameAs 2092446204 @default.
- W2092446204 citedByCount "6" @default.
- W2092446204 crossrefType "journal-article" @default.
- W2092446204 hasAuthorship W2092446204A5034523412 @default.
- W2092446204 hasAuthorship W2092446204A5060928089 @default.
- W2092446204 hasAuthorship W2092446204A5064117907 @default.
- W2092446204 hasAuthorship W2092446204A5072150282 @default.
- W2092446204 hasConcept C126322002 @default.
- W2092446204 hasConcept C170493617 @default.
- W2092446204 hasConcept C178853913 @default.
- W2092446204 hasConcept C199360897 @default.
- W2092446204 hasConcept C2776174256 @default.
- W2092446204 hasConcept C2776271928 @default.
- W2092446204 hasConcept C2778151854 @default.
- W2092446204 hasConcept C2778468042 @default.
- W2092446204 hasConcept C2778715236 @default.
- W2092446204 hasConcept C2780283014 @default.
- W2092446204 hasConcept C2909341992 @default.
- W2092446204 hasConcept C41008148 @default.
- W2092446204 hasConcept C42219234 @default.
- W2092446204 hasConcept C71924100 @default.
- W2092446204 hasConcept C98274493 @default.
- W2092446204 hasConceptScore W2092446204C126322002 @default.
- W2092446204 hasConceptScore W2092446204C170493617 @default.
- W2092446204 hasConceptScore W2092446204C178853913 @default.
- W2092446204 hasConceptScore W2092446204C199360897 @default.
- W2092446204 hasConceptScore W2092446204C2776174256 @default.
- W2092446204 hasConceptScore W2092446204C2776271928 @default.
- W2092446204 hasConceptScore W2092446204C2778151854 @default.
- W2092446204 hasConceptScore W2092446204C2778468042 @default.
- W2092446204 hasConceptScore W2092446204C2778715236 @default.
- W2092446204 hasConceptScore W2092446204C2780283014 @default.
- W2092446204 hasConceptScore W2092446204C2909341992 @default.
- W2092446204 hasConceptScore W2092446204C41008148 @default.
- W2092446204 hasConceptScore W2092446204C42219234 @default.
- W2092446204 hasConceptScore W2092446204C71924100 @default.
- W2092446204 hasConceptScore W2092446204C98274493 @default.
- W2092446204 hasIssue "S1" @default.
- W2092446204 hasLocation W20924462041 @default.
- W2092446204 hasLocation W20924462042 @default.
- W2092446204 hasOpenAccess W2092446204 @default.
- W2092446204 hasPrimaryLocation W20924462041 @default.
- W2092446204 hasRelatedWork W2018420745 @default.
- W2092446204 hasRelatedWork W2039171728 @default.
- W2092446204 hasRelatedWork W2066826675 @default.
- W2092446204 hasRelatedWork W2068634065 @default.
- W2092446204 hasRelatedWork W2409050491 @default.
- W2092446204 hasRelatedWork W2412311080 @default.
- W2092446204 hasRelatedWork W2412372585 @default.
- W2092446204 hasRelatedWork W2429151256 @default.
- W2092446204 hasRelatedWork W4255460854 @default.
- W2092446204 hasRelatedWork W4300446836 @default.
- W2092446204 hasVolume "26" @default.
- W2092446204 isParatext "false" @default.
- W2092446204 isRetracted "false" @default.
- W2092446204 magId "2092446204" @default.
- W2092446204 workType "article" @default.