FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092449508> ?p ?o ?g. }

• W2092449508 endingPage "943" @default.
• W2092449508 startingPage "933" @default.
• W2092449508 abstract "Myeloproliferation with prominent eosinophilia is associated with rearrangements of PDGFR-A or -B. The most common rearrangement is FIP1L1-PDGFRA (FP). The majority of patients with PDGFR-rearranged myeloproliferation respond to treatment with imatinib. In contrast to BCR–ABL-positive chronic myelogenous leukemia, only few cases of imatinib resistance and mutations of the FP kinase domain have been described so far. We hypothesized that the number of critical residues mediating imatinib resistance in FP in contrast to BCR–ABL might be limited. We performed an established systematic and comprehensive in vitro resistance screen to determine the pattern and frequency of possible TKI resistance mutations in FP. We identified 27 different FP kinase domain mutations including 25 novel variants, which attenuated response to imatinib, nilotinib or sorafenib. However, the majority of these exchanges did not confer complete inhibitor resistance. At clinically achievable drug concentrations, FP/T674I predominated with imatinib, whereas with nilotinib and sorafenib, FP/D842V and the compound mutation T674I+T874I became prevalent. Our results suggest that the PDGFR kinase domain contains a limited number of residues where exchanges critically interfere with binding of and inhibition by available PDGFR kinase inhibitors at achievable concentrations, which might explain the low frequency of imatinib resistance in this patient population. In addition, these findings would help to select the appropriate second-line drug in cases of imatinib-resistant disease and may be translated to other neoplasms driven by activated forms of PDGFR-A or -B." @default.
• W2092449508 created "2016-06-24" @default.
• W2092449508 creator A5023612531 @default.
• W2092449508 creator A5053887032 @default.
• W2092449508 creator A5063901716 @default.
• W2092449508 creator A5066200247 @default.
• W2092449508 creator A5069241167 @default.
• W2092449508 creator A5070419297 @default.
• W2092449508 creator A5087035670 @default.
• W2092449508 creator A5088789978 @default.
• W2092449508 date "2010-10-25" @default.
• W2092449508 modified "2023-09-25" @default.
• W2092449508 title "The low frequency of clinical resistance to PDGFR inhibitors in myeloid neoplasms with abnormalities of PDGFRA might be related to the limited repertoire of possible PDGFRA kinase domain mutations in vitro" @default.
• W2092449508 cites W1965871143 @default.
• W2092449508 cites W1978330466 @default.
• W2092449508 cites W1978514731 @default.
• W2092449508 cites W1985177017 @default.
• W2092449508 cites W1993099484 @default.
• W2092449508 cites W1995670055 @default.
• W2092449508 cites W1997360163 @default.
• W2092449508 cites W1999614615 @default.
• W2092449508 cites W2012952884 @default.
• W2092449508 cites W2014307638 @default.
• W2092449508 cites W2015663870 @default.
• W2092449508 cites W2016419233 @default.
• W2092449508 cites W2020164940 @default.
• W2092449508 cites W2024510824 @default.
• W2092449508 cites W2051728915 @default.
• W2092449508 cites W2053343706 @default.
• W2092449508 cites W2054251966 @default.
• W2092449508 cites W2056075946 @default.
• W2092449508 cites W2065514651 @default.
• W2092449508 cites W2066998725 @default.
• W2092449508 cites W2075428599 @default.
• W2092449508 cites W2077187679 @default.
• W2092449508 cites W2080251370 @default.
• W2092449508 cites W2080732293 @default.
• W2092449508 cites W2080924817 @default.
• W2092449508 cites W2083353096 @default.
• W2092449508 cites W2085402944 @default.
• W2092449508 cites W2086082854 @default.
• W2092449508 cites W2095226581 @default.
• W2092449508 cites W2101986793 @default.
• W2092449508 cites W2102769930 @default.
• W2092449508 cites W2103304755 @default.
• W2092449508 cites W2113230030 @default.
• W2092449508 cites W2113344287 @default.
• W2092449508 cites W2116177733 @default.
• W2092449508 cites W2123499987 @default.
• W2092449508 cites W2124196948 @default.
• W2092449508 cites W2125135039 @default.
• W2092449508 cites W2126235458 @default.
• W2092449508 cites W2135338251 @default.
• W2092449508 cites W2150953357 @default.
• W2092449508 cites W2154169171 @default.
• W2092449508 cites W2159863363 @default.
• W2092449508 cites W2160215400 @default.
• W2092449508 cites W2166654361 @default.
• W2092449508 cites W2168437437 @default.
• W2092449508 cites W2169014486 @default.
• W2092449508 cites W4293245940 @default.
• W2092449508 doi "https://doi.org/10.1038/onc.2010.476" @default.
• W2092449508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20972453" @default.
• W2092449508 hasPublicationYear "2010" @default.
• W2092449508 type Work @default.
• W2092449508 sameAs 2092449508 @default.
• W2092449508 citedByCount "28" @default.
• W2092449508 countsByYear W20924495082012 @default.
• W2092449508 countsByYear W20924495082013 @default.
• W2092449508 countsByYear W20924495082014 @default.
• W2092449508 countsByYear W20924495082015 @default.
• W2092449508 countsByYear W20924495082016 @default.
• W2092449508 countsByYear W20924495082017 @default.
• W2092449508 countsByYear W20924495082018 @default.
• W2092449508 countsByYear W20924495082020 @default.
• W2092449508 countsByYear W20924495082023 @default.
• W2092449508 crossrefType "journal-article" @default.
• W2092449508 hasAuthorship W2092449508A5023612531 @default.
• W2092449508 hasAuthorship W2092449508A5053887032 @default.
• W2092449508 hasAuthorship W2092449508A5063901716 @default.
• W2092449508 hasAuthorship W2092449508A5066200247 @default.
• W2092449508 hasAuthorship W2092449508A5069241167 @default.
• W2092449508 hasAuthorship W2092449508A5070419297 @default.
• W2092449508 hasAuthorship W2092449508A5087035670 @default.
• W2092449508 hasAuthorship W2092449508A5088789978 @default.
• W2092449508 hasBestOaLocation W20924495081 @default.
• W2092449508 hasConcept C104317684 @default.
• W2092449508 hasConcept C121608353 @default.
• W2092449508 hasConcept C125418893 @default.
• W2092449508 hasConcept C143065580 @default.
• W2092449508 hasConcept C16930146 @default.
• W2092449508 hasConcept C203014093 @default.
• W2092449508 hasConcept C2775922572 @default.
• W2092449508 hasConcept C2776960273 @default.
• W2092449508 hasConcept C2777413986 @default.
• W2092449508 hasConcept C2777583451 @default.
• W2092449508 hasConcept C2778019345 @default.
• W2092449508 hasConcept C2778461978 @default.

• next