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- W209245611 abstract "This chapter describes the role of carbohydrates in the action of gonadotropins as very little is known about the role played by the carbohydrate in the mechanism of hormone action. Primary studies of the role of the carbohydrate in the biological function of gonadotropins have revealed that the elimination of sialic acid residues by neuraminidase digestion generally reduces their activity when evaluated in vivo because the asialo gonadotropins are eliminated from circulation quickly. However, structural studies of hCG have shown that neuraminidase treatment exposes terminal galactose residues. On the whole, glycoproteins with exposes terminal galactose residues have a short in vivo half-life because they bind with pleasure to a glycoprotein binding protein, which is to be found on the plasma membranes of hepatocytes that recognizes the non-reducing terminal galactose residues." @default.
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- W209245611 date "1978-01-01" @default.
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- W209245611 title "Role of Carbohydrate in the Action of Gonadotropins" @default.
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- W209245611 doi "https://doi.org/10.1016/b978-0-12-526303-0.50015-1" @default.
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