Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092470007> ?p ?o ?g. }
- W2092470007 endingPage "15897" @default.
- W2092470007 startingPage "15892" @default.
- W2092470007 abstract "Significance Several in situ click chemistry studies have been reported. To date, there is evidence to indicate that proteins act as mold between azide and alkyne fragments by X-ray analysis of protein–ligand complexes. However, only “postclick” structural evidence has been available. We succeeded in obtaining crystal structures of a chitinase complexed with an azide inhibitor and an O -allyl oxime fragment as a mimic of a click partner, revealing a mechanism for accelerating triazole formation in chitinase. This is an example to express the “preclick” state of in situ click chemistry and a demonstration to show that the in situ click chemistry approach will benefit from this analysis for future plans. We also performed density functional theory calculations to explore the chitinase-contributed Huisgen cycloaddition." @default.
- W2092470007 created "2016-06-24" @default.
- W2092470007 creator A5004389476 @default.
- W2092470007 creator A5005147038 @default.
- W2092470007 creator A5019913014 @default.
- W2092470007 creator A5026832980 @default.
- W2092470007 creator A5034039928 @default.
- W2092470007 creator A5044189648 @default.
- W2092470007 creator A5045164227 @default.
- W2092470007 creator A5053994773 @default.
- W2092470007 creator A5075089132 @default.
- W2092470007 creator A5077401880 @default.
- W2092470007 creator A5078878264 @default.
- W2092470007 creator A5086236227 @default.
- W2092470007 creator A5087279007 @default.
- W2092470007 creator A5088787936 @default.
- W2092470007 date "2013-09-16" @default.
- W2092470007 modified "2023-10-18" @default.
- W2092470007 title "Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor" @default.
- W2092470007 cites W1539796472 @default.
- W2092470007 cites W1772341111 @default.
- W2092470007 cites W1780849736 @default.
- W2092470007 cites W1964545163 @default.
- W2092470007 cites W1965780953 @default.
- W2092470007 cites W1968652549 @default.
- W2092470007 cites W1971170829 @default.
- W2092470007 cites W1987911729 @default.
- W2092470007 cites W1988066093 @default.
- W2092470007 cites W1991646180 @default.
- W2092470007 cites W1997173539 @default.
- W2092470007 cites W2001865803 @default.
- W2092470007 cites W2001982529 @default.
- W2092470007 cites W2008742048 @default.
- W2092470007 cites W2011843450 @default.
- W2092470007 cites W2021480093 @default.
- W2092470007 cites W2041887070 @default.
- W2092470007 cites W2068348723 @default.
- W2092470007 cites W2071972254 @default.
- W2092470007 cites W2072144575 @default.
- W2092470007 cites W2077538072 @default.
- W2092470007 cites W2081912151 @default.
- W2092470007 cites W2084045035 @default.
- W2092470007 cites W2084592446 @default.
- W2092470007 cites W2087765372 @default.
- W2092470007 cites W2090919511 @default.
- W2092470007 cites W2093175298 @default.
- W2092470007 cites W2098303032 @default.
- W2092470007 cites W2108921801 @default.
- W2092470007 cites W2109293107 @default.
- W2092470007 cites W2114367386 @default.
- W2092470007 cites W2122199548 @default.
- W2092470007 cites W2124026197 @default.
- W2092470007 cites W2129832960 @default.
- W2092470007 cites W2140900244 @default.
- W2092470007 cites W2145662716 @default.
- W2092470007 cites W2146080841 @default.
- W2092470007 cites W2146910635 @default.
- W2092470007 cites W2150804079 @default.
- W2092470007 cites W2152147380 @default.
- W2092470007 cites W2155082155 @default.
- W2092470007 cites W2159211495 @default.
- W2092470007 cites W2164984955 @default.
- W2092470007 cites W2165464520 @default.
- W2092470007 cites W2951960937 @default.
- W2092470007 doi "https://doi.org/10.1073/pnas.1315049110" @default.
- W2092470007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3791779" @default.
- W2092470007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24043811" @default.
- W2092470007 hasPublicationYear "2013" @default.
- W2092470007 type Work @default.
- W2092470007 sameAs 2092470007 @default.
- W2092470007 citedByCount "24" @default.
- W2092470007 countsByYear W20924700072014 @default.
- W2092470007 countsByYear W20924700072015 @default.
- W2092470007 countsByYear W20924700072016 @default.
- W2092470007 countsByYear W20924700072017 @default.
- W2092470007 countsByYear W20924700072018 @default.
- W2092470007 countsByYear W20924700072019 @default.
- W2092470007 countsByYear W20924700072020 @default.
- W2092470007 countsByYear W20924700072022 @default.
- W2092470007 countsByYear W20924700072023 @default.
- W2092470007 crossrefType "journal-article" @default.
- W2092470007 hasAuthorship W2092470007A5004389476 @default.
- W2092470007 hasAuthorship W2092470007A5005147038 @default.
- W2092470007 hasAuthorship W2092470007A5019913014 @default.
- W2092470007 hasAuthorship W2092470007A5026832980 @default.
- W2092470007 hasAuthorship W2092470007A5034039928 @default.
- W2092470007 hasAuthorship W2092470007A5044189648 @default.
- W2092470007 hasAuthorship W2092470007A5045164227 @default.
- W2092470007 hasAuthorship W2092470007A5053994773 @default.
- W2092470007 hasAuthorship W2092470007A5075089132 @default.
- W2092470007 hasAuthorship W2092470007A5077401880 @default.
- W2092470007 hasAuthorship W2092470007A5078878264 @default.
- W2092470007 hasAuthorship W2092470007A5086236227 @default.
- W2092470007 hasAuthorship W2092470007A5087279007 @default.
- W2092470007 hasAuthorship W2092470007A5088787936 @default.
- W2092470007 hasBestOaLocation W20924700071 @default.
- W2092470007 hasConcept C161790260 @default.
- W2092470007 hasConcept C178790620 @default.