Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092471844> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2092471844 endingPage "215" @default.
- W2092471844 startingPage "207" @default.
- W2092471844 abstract "Aggressive chemotherapy of myelodysplastic syndromes is rarely feasible because these disorders predominantly occur in elderly patients who often have concurrent illnesses. Alternative treatment modalities must therefore be evaluated. This review summarizes the results that have been obtained with low-dose chemotherapy, especially with low-dose cytosine arabinoside (Ara-C). Overall response rates to treatment with low-dose Ara-C are about 40%, with some 20% of patients achieving a complete remission. Transition of MDS to AML does not reduce the probability of response. The therapeutic outcome cannot be reliably predicted by clinical or experimental parameters. Hematological toxicity is substantial, with approximately 10-25% treatment-related deaths. Duration of response is short and rarely exceeds one year. In terms of overall survival, low dose Ara-C does not appear to be superior to supportive care only. Other cytotoxic agents have not been studied in detail, but data available do not suggest an appreciable advantage over Ara-C. Before denying low-dose chemotherapy a helpful role in MDS, randomized studies should concentrate on those patients who can be expected to derive the greatest benefit. Because of their short survival, patients with RAEBt or those transformed to overt leukemia are such candidates." @default.
- W2092471844 created "2016-06-24" @default.
- W2092471844 creator A5042020284 @default.
- W2092471844 creator A5090793417 @default.
- W2092471844 date "1992-03-01" @default.
- W2092471844 modified "2023-10-13" @default.
- W2092471844 title "The role of low-dose chemotherapy in myelodysplastic syndromes" @default.
- W2092471844 cites W121813311 @default.
- W2092471844 cites W1832802185 @default.
- W2092471844 cites W1971102604 @default.
- W2092471844 cites W1976106603 @default.
- W2092471844 cites W1976223687 @default.
- W2092471844 cites W1983068803 @default.
- W2092471844 cites W1984510961 @default.
- W2092471844 cites W1995388830 @default.
- W2092471844 cites W1995809475 @default.
- W2092471844 cites W1995969368 @default.
- W2092471844 cites W2002622278 @default.
- W2092471844 cites W2012085613 @default.
- W2092471844 cites W2014405550 @default.
- W2092471844 cites W2015627245 @default.
- W2092471844 cites W2032324968 @default.
- W2092471844 cites W2045507683 @default.
- W2092471844 cites W2047706911 @default.
- W2092471844 cites W2047915360 @default.
- W2092471844 cites W2050214747 @default.
- W2092471844 cites W2062661083 @default.
- W2092471844 cites W2067539669 @default.
- W2092471844 cites W2070522080 @default.
- W2092471844 cites W2072563798 @default.
- W2092471844 cites W2073280756 @default.
- W2092471844 cites W2075768723 @default.
- W2092471844 cites W2078722387 @default.
- W2092471844 cites W2085686347 @default.
- W2092471844 cites W2088575676 @default.
- W2092471844 cites W2091268684 @default.
- W2092471844 cites W2105559291 @default.
- W2092471844 cites W2123007686 @default.
- W2092471844 cites W2154751476 @default.
- W2092471844 cites W2155355600 @default.
- W2092471844 cites W2165846604 @default.
- W2092471844 cites W2268843230 @default.
- W2092471844 cites W2468107651 @default.
- W2092471844 cites W4235775400 @default.
- W2092471844 cites W4245548496 @default.
- W2092471844 cites W4247431846 @default.
- W2092471844 cites W55409762 @default.
- W2092471844 cites W2032115523 @default.
- W2092471844 doi "https://doi.org/10.1016/0145-2126(92)90058-f" @default.
- W2092471844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1560670" @default.
- W2092471844 hasPublicationYear "1992" @default.
- W2092471844 type Work @default.
- W2092471844 sameAs 2092471844 @default.
- W2092471844 citedByCount "15" @default.
- W2092471844 countsByYear W20924718442012 @default.
- W2092471844 crossrefType "journal-article" @default.
- W2092471844 hasAuthorship W2092471844A5042020284 @default.
- W2092471844 hasAuthorship W2092471844A5090793417 @default.
- W2092471844 hasConcept C126322002 @default.
- W2092471844 hasConcept C143998085 @default.
- W2092471844 hasConcept C2776694085 @default.
- W2092471844 hasConcept C2778041864 @default.
- W2092471844 hasConcept C2778461978 @default.
- W2092471844 hasConcept C2780007613 @default.
- W2092471844 hasConcept C2780817109 @default.
- W2092471844 hasConcept C29730261 @default.
- W2092471844 hasConcept C71924100 @default.
- W2092471844 hasConceptScore W2092471844C126322002 @default.
- W2092471844 hasConceptScore W2092471844C143998085 @default.
- W2092471844 hasConceptScore W2092471844C2776694085 @default.
- W2092471844 hasConceptScore W2092471844C2778041864 @default.
- W2092471844 hasConceptScore W2092471844C2778461978 @default.
- W2092471844 hasConceptScore W2092471844C2780007613 @default.
- W2092471844 hasConceptScore W2092471844C2780817109 @default.
- W2092471844 hasConceptScore W2092471844C29730261 @default.
- W2092471844 hasConceptScore W2092471844C71924100 @default.
- W2092471844 hasIssue "3" @default.
- W2092471844 hasLocation W20924718441 @default.
- W2092471844 hasLocation W20924718442 @default.
- W2092471844 hasOpenAccess W2092471844 @default.
- W2092471844 hasPrimaryLocation W20924718441 @default.
- W2092471844 hasRelatedWork W2071924625 @default.
- W2092471844 hasRelatedWork W2099215382 @default.
- W2092471844 hasRelatedWork W2165783631 @default.
- W2092471844 hasRelatedWork W2169994420 @default.
- W2092471844 hasRelatedWork W2405192714 @default.
- W2092471844 hasRelatedWork W2921669635 @default.
- W2092471844 hasRelatedWork W3131064358 @default.
- W2092471844 hasRelatedWork W3202496217 @default.
- W2092471844 hasRelatedWork W321613470 @default.
- W2092471844 hasRelatedWork W4386208612 @default.
- W2092471844 hasVolume "16" @default.
- W2092471844 isParatext "false" @default.
- W2092471844 isRetracted "false" @default.
- W2092471844 magId "2092471844" @default.
- W2092471844 workType "article" @default.