Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092478539> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2092478539 endingPage "823" @default.
- W2092478539 startingPage "819" @default.
- W2092478539 abstract "Abstract Background Inherited genetic variants in critical genes can putatively modulate susceptibility to childhood acute lymphoblastic leukemia (ALL). Methods We used allelic discrimination method to genotype 19 polymorphisms in the transforming growth factor‐β1 ( TGF‐β1 ) , transforming growth factor‐β receptor 1 ( TGF‐βR1 ) and transforming growth factor‐β receptor 2 ( TGF‐βR2 ) genes in 460 cases of childhood acute ALL and 552 ethnically matched controls. The genotyped polymorphisms included functional and tagging variants to cover the three genes in entirety. We used multidimensionality reduction (MDR) method to test effect of multiple genes on disease susceptibility. In order to increase statistical power and detect susceptibility variants not directly genotyped in this study, we used imputation using HapMap data. Results None of the genotyped polymorphisms or the consequent haplotypes showed any association with risk modulation. The results, however, did show a marginal association (odds ratio OR 0.76, 95% confidence interval CI 0.59–0.97) of the variant allele for the rs10417924 polymorphism located at 3′untranslated region of the TGF‐β1 gene with the B‐cell lineage ALL. No other polymorphism showed any association with childhood ALL susceptibility. A signal of marginal significance for the rs10417924 polymorphism in the TGF‐β1 gene in B‐cell lineage ALL showed up with both MDR and imputation techniques. Conclusion These data rule out the role of polymorphisms in the TGF‐β1, TGF‐βR1 and TGF‐βR2 genes in susceptibility to childhood ALL. However, for B‐lineage ALL, the role of the rs10417924 polymorphism in TGF‐β1 gene needs further investigation. Pediatr Blood Cancer 2009;52:819–823. © 2009 Wiley‐Liss, Inc." @default.
- W2092478539 created "2016-06-24" @default.
- W2092478539 creator A5000885936 @default.
- W2092478539 creator A5020812442 @default.
- W2092478539 creator A5023918175 @default.
- W2092478539 creator A5039859319 @default.
- W2092478539 creator A5049051373 @default.
- W2092478539 creator A5053884420 @default.
- W2092478539 creator A5054289982 @default.
- W2092478539 creator A5090212645 @default.
- W2092478539 date "2009-02-19" @default.
- W2092478539 modified "2023-10-12" @default.
- W2092478539 title "A case-control study of childhood acute lymphoblastic leukaemia and polymorphisms in the TGF-β and receptor genes" @default.
- W2092478539 cites W1968340154 @default.
- W2092478539 cites W1991190482 @default.
- W2092478539 cites W2005594050 @default.
- W2092478539 cites W2008047653 @default.
- W2092478539 cites W2019242560 @default.
- W2092478539 cites W2021263701 @default.
- W2092478539 cites W2037038224 @default.
- W2092478539 cites W2070468543 @default.
- W2092478539 cites W2084383474 @default.
- W2092478539 cites W2130714065 @default.
- W2092478539 cites W2131482272 @default.
- W2092478539 cites W2136819827 @default.
- W2092478539 cites W2149791927 @default.
- W2092478539 cites W2154568166 @default.
- W2092478539 cites W2154572047 @default.
- W2092478539 cites W2165933909 @default.
- W2092478539 cites W2345598503 @default.
- W2092478539 doi "https://doi.org/10.1002/pbc.21971" @default.
- W2092478539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19229971" @default.
- W2092478539 hasPublicationYear "2009" @default.
- W2092478539 type Work @default.
- W2092478539 sameAs 2092478539 @default.
- W2092478539 citedByCount "8" @default.
- W2092478539 countsByYear W20924785392012 @default.
- W2092478539 countsByYear W20924785392014 @default.
- W2092478539 countsByYear W20924785392015 @default.
- W2092478539 countsByYear W20924785392021 @default.
- W2092478539 crossrefType "journal-article" @default.
- W2092478539 hasAuthorship W2092478539A5000885936 @default.
- W2092478539 hasAuthorship W2092478539A5020812442 @default.
- W2092478539 hasAuthorship W2092478539A5023918175 @default.
- W2092478539 hasAuthorship W2092478539A5039859319 @default.
- W2092478539 hasAuthorship W2092478539A5049051373 @default.
- W2092478539 hasAuthorship W2092478539A5053884420 @default.
- W2092478539 hasAuthorship W2092478539A5054289982 @default.
- W2092478539 hasAuthorship W2092478539A5090212645 @default.
- W2092478539 hasConcept C104317684 @default.
- W2092478539 hasConcept C118131993 @default.
- W2092478539 hasConcept C126322002 @default.
- W2092478539 hasConcept C134018914 @default.
- W2092478539 hasConcept C135763542 @default.
- W2092478539 hasConcept C156957248 @default.
- W2092478539 hasConcept C157410074 @default.
- W2092478539 hasConcept C177580304 @default.
- W2092478539 hasConcept C180754005 @default.
- W2092478539 hasConcept C197754878 @default.
- W2092478539 hasConcept C37463918 @default.
- W2092478539 hasConcept C54355233 @default.
- W2092478539 hasConcept C71924100 @default.
- W2092478539 hasConcept C86803240 @default.
- W2092478539 hasConceptScore W2092478539C104317684 @default.
- W2092478539 hasConceptScore W2092478539C118131993 @default.
- W2092478539 hasConceptScore W2092478539C126322002 @default.
- W2092478539 hasConceptScore W2092478539C134018914 @default.
- W2092478539 hasConceptScore W2092478539C135763542 @default.
- W2092478539 hasConceptScore W2092478539C156957248 @default.
- W2092478539 hasConceptScore W2092478539C157410074 @default.
- W2092478539 hasConceptScore W2092478539C177580304 @default.
- W2092478539 hasConceptScore W2092478539C180754005 @default.
- W2092478539 hasConceptScore W2092478539C197754878 @default.
- W2092478539 hasConceptScore W2092478539C37463918 @default.
- W2092478539 hasConceptScore W2092478539C54355233 @default.
- W2092478539 hasConceptScore W2092478539C71924100 @default.
- W2092478539 hasConceptScore W2092478539C86803240 @default.
- W2092478539 hasIssue "7" @default.
- W2092478539 hasLocation W20924785391 @default.
- W2092478539 hasLocation W20924785392 @default.
- W2092478539 hasOpenAccess W2092478539 @default.
- W2092478539 hasPrimaryLocation W20924785391 @default.
- W2092478539 hasRelatedWork W1997183765 @default.
- W2092478539 hasRelatedWork W2002755595 @default.
- W2092478539 hasRelatedWork W2005998210 @default.
- W2092478539 hasRelatedWork W2036715394 @default.
- W2092478539 hasRelatedWork W2057613402 @default.
- W2092478539 hasRelatedWork W2079847480 @default.
- W2092478539 hasRelatedWork W2208141744 @default.
- W2092478539 hasRelatedWork W2465684894 @default.
- W2092478539 hasRelatedWork W2468405568 @default.
- W2092478539 hasRelatedWork W3148557437 @default.
- W2092478539 hasVolume "52" @default.
- W2092478539 isParatext "false" @default.
- W2092478539 isRetracted "false" @default.
- W2092478539 magId "2092478539" @default.
- W2092478539 workType "article" @default.