FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092483284> ?p ?o ?g. }

• W2092483284 endingPage "924" @default.
• W2092483284 startingPage "916" @default.
• W2092483284 abstract "CD160 is expressed by human and mouse natural killer (NK) cells and other cytotoxic lymphocyte subpopulations. CD160 is mostly expressed as a trimeric 83kDa glycosylphosphatidylinositol (GPI)-anchored activating NK receptor, cleaved upon IL-15 stimulation in a secreted trimeric soluble form (sCD160) that binds to major histocompatibility complex (MHC) class I molecules, while a transmembrane isoform appears. sCD160 exhibits immunoregulatory function as it inhibits CD8+ T-lymphocyte cytotoxic activity. We show that human mast cells (MCs) express CD160. In human and mouse skin, resident MCs expressed CD160, whereas in C57BL/6-KitW-sh/W-sh mice, CD160+ cells were only identified at the site of reconstitution with syngeneic cultured MCs. In the human mast cell line, HMC-1, we only identified the transcripts of the GPI-anchored CD160 isoform. Furthermore, CD160 was identified in HMC-1 and mouse MC supernatants, suggesting that MCs release sCD160. Supporting this hypothesis, HMC-1 express the GPI-specific phospholipase D variant 2 involved in the NK lymphocyte membrane cleavage of CD160, and morphological studies highlighted a relative loss of CD160 expression in inflammatory skin sites, where MC degranulation is expected to occur. We also demonstrated an inhibition of T-cell cytotoxicity by HMC-1 supernatant that was partially reversed by anti-CD160 mAb. In conclusion, sCD160, produced by MCs, may have a role in T-cell–MC interactions in vivo. CD160 is expressed by human and mouse natural killer (NK) cells and other cytotoxic lymphocyte subpopulations. CD160 is mostly expressed as a trimeric 83kDa glycosylphosphatidylinositol (GPI)-anchored activating NK receptor, cleaved upon IL-15 stimulation in a secreted trimeric soluble form (sCD160) that binds to major histocompatibility complex (MHC) class I molecules, while a transmembrane isoform appears. sCD160 exhibits immunoregulatory function as it inhibits CD8+ T-lymphocyte cytotoxic activity. We show that human mast cells (MCs) express CD160. In human and mouse skin, resident MCs expressed CD160, whereas in C57BL/6-KitW-sh/W-sh mice, CD160+ cells were only identified at the site of reconstitution with syngeneic cultured MCs. In the human mast cell line, HMC-1, we only identified the transcripts of the GPI-anchored CD160 isoform. Furthermore, CD160 was identified in HMC-1 and mouse MC supernatants, suggesting that MCs release sCD160. Supporting this hypothesis, HMC-1 express the GPI-specific phospholipase D variant 2 involved in the NK lymphocyte membrane cleavage of CD160, and morphological studies highlighted a relative loss of CD160 expression in inflammatory skin sites, where MC degranulation is expected to occur. We also demonstrated an inhibition of T-cell cytotoxicity by HMC-1 supernatant that was partially reversed by anti-CD160 mAb. In conclusion, sCD160, produced by MCs, may have a role in T-cell–MC interactions in vivo. bone marrow mast cell fetal skin mast cell glycosylphosphatidylinositol herpes virus entry mediator mast cell major histocompatibility complex natural killer phospholipase D peritoneal mast cell" @default.
• W2092483284 created "2016-06-24" @default.
• W2092483284 creator A5012521997 @default.
• W2092483284 creator A5025537277 @default.
• W2092483284 creator A5040446667 @default.
• W2092483284 creator A5041781725 @default.
• W2092483284 creator A5061551018 @default.
• W2092483284 creator A5082612491 @default.
• W2092483284 creator A5085729205 @default.
• W2092483284 date "2011-04-01" @default.
• W2092483284 modified "2023-10-16" @default.
• W2092483284 title "Human and Mouse Mast Cells Express and Secrete the GPI-Anchored Isoform of CD160" @default.
• W2092483284 cites W1508629699 @default.
• W2092483284 cites W1522362732 @default.
• W2092483284 cites W1536918723 @default.
• W2092483284 cites W1548484817 @default.
• W2092483284 cites W1639310471 @default.
• W2092483284 cites W1816746890 @default.
• W2092483284 cites W1936646108 @default.
• W2092483284 cites W1973792501 @default.
• W2092483284 cites W1975341000 @default.
• W2092483284 cites W1975800926 @default.
• W2092483284 cites W1980470045 @default.
• W2092483284 cites W1982709334 @default.
• W2092483284 cites W1997153240 @default.
• W2092483284 cites W2000648336 @default.
• W2092483284 cites W2002176900 @default.
• W2092483284 cites W2002474633 @default.
• W2092483284 cites W2004923089 @default.
• W2092483284 cites W2008652234 @default.
• W2092483284 cites W2015975112 @default.
• W2092483284 cites W2017892482 @default.
• W2092483284 cites W2019533704 @default.
• W2092483284 cites W2024533943 @default.
• W2092483284 cites W2034262749 @default.
• W2092483284 cites W2035023446 @default.
• W2092483284 cites W2037231532 @default.
• W2092483284 cites W2045200013 @default.
• W2092483284 cites W2052855154 @default.
• W2092483284 cites W2052965227 @default.
• W2092483284 cites W2055313665 @default.
• W2092483284 cites W2058854516 @default.
• W2092483284 cites W2064990965 @default.
• W2092483284 cites W2076124970 @default.
• W2092483284 cites W2093953626 @default.
• W2092483284 cites W2099905116 @default.
• W2092483284 cites W2102930679 @default.
• W2092483284 cites W2105383040 @default.
• W2092483284 cites W2106301295 @default.
• W2092483284 cites W2106875608 @default.
• W2092483284 cites W2113844670 @default.
• W2092483284 cites W2115809232 @default.
• W2092483284 cites W2126304801 @default.
• W2092483284 cites W2126437677 @default.
• W2092483284 cites W2141325184 @default.
• W2092483284 cites W2151105312 @default.
• W2092483284 cites W2164746699 @default.
• W2092483284 cites W2172263281 @default.
• W2092483284 doi "https://doi.org/10.1038/jid.2010.412" @default.
• W2092483284 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21191401" @default.
• W2092483284 hasPublicationYear "2011" @default.
• W2092483284 type Work @default.
• W2092483284 sameAs 2092483284 @default.
• W2092483284 citedByCount "15" @default.
• W2092483284 countsByYear W20924832842012 @default.
• W2092483284 countsByYear W20924832842014 @default.
• W2092483284 countsByYear W20924832842015 @default.
• W2092483284 countsByYear W20924832842016 @default.
• W2092483284 countsByYear W20924832842018 @default.
• W2092483284 countsByYear W20924832842020 @default.
• W2092483284 countsByYear W20924832842021 @default.
• W2092483284 countsByYear W20924832842022 @default.
• W2092483284 crossrefType "journal-article" @default.
• W2092483284 hasAuthorship W2092483284A5012521997 @default.
• W2092483284 hasAuthorship W2092483284A5025537277 @default.
• W2092483284 hasAuthorship W2092483284A5040446667 @default.
• W2092483284 hasAuthorship W2092483284A5041781725 @default.
• W2092483284 hasAuthorship W2092483284A5061551018 @default.
• W2092483284 hasAuthorship W2092483284A5082612491 @default.
• W2092483284 hasAuthorship W2092483284A5085729205 @default.
• W2092483284 hasBestOaLocation W20924832841 @default.
• W2092483284 hasConcept C153911025 @default.
• W2092483284 hasConcept C154317977 @default.
• W2092483284 hasConcept C167672396 @default.
• W2092483284 hasConcept C170493617 @default.
• W2092483284 hasConcept C185592680 @default.
• W2092483284 hasConcept C202751555 @default.
• W2092483284 hasConcept C203014093 @default.
• W2092483284 hasConcept C207936829 @default.
• W2092483284 hasConcept C49802076 @default.
• W2092483284 hasConcept C55493867 @default.
• W2092483284 hasConcept C86803240 @default.
• W2092483284 hasConcept C8891405 @default.
• W2092483284 hasConcept C95444343 @default.
• W2092483284 hasConceptScore W2092483284C153911025 @default.
• W2092483284 hasConceptScore W2092483284C154317977 @default.
• W2092483284 hasConceptScore W2092483284C167672396 @default.
• W2092483284 hasConceptScore W2092483284C170493617 @default.

• next