FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092484297> ?p ?o ?g. }

• W2092484297 abstract "Nuclear factor-kappaB (NF-κB) is an inducible transcription factor that plays a key role in inflammation and immune responses, as well as in the regulation of cell proliferation and survival. Previous studies by our group and others have demonstrated that porcine reproductive and respiratory syndrome virus (PRRSV) infection could activate NF-κB in MARC-145 cells and alveolar macrophages. The nucleocapsid (N) protein was identified as an NF-κB activator among the structural proteins encoded by PRRSV; however, it remains unclear whether the nonstructural proteins (Nsps) contribute to NF-κB activation. In this study, we identified which Nsps can activate NF-κB and investigated the potential mechanism(s) by which they act.By screening the individual Nsps of PRRSV strain WUH3, Nsp2 exhibited great potential to activate NF-κB in MARC-145 and HeLa cells. Overexpression of Nsp2 induced IκBα degradation and nuclear translocation of NF-κB. Furthermore, Nsp2 also induced NF-κB-dependent inflammatory factors, including interleukin (IL)-6, IL-8, COX-2, and RANTES. Compared with the Nsp2 of the classical PRRSV strain, the Nsp2 of highly pathogenic PRRSV (HP-PRRSV) strains that possess a 30 amino acid (aa) deletion in Nsp2 displayed greater NF-κB activation. However, the 30-aa deletion was demonstrated to not be associated with NF-κB activation. Further functional domain analyses revealed that the hypervariable region (HV) of Nsp2 was essential for NF-κB activation.Taken together, these data indicate that PRRSV Nsp2 is a multifunctional protein participating in the modulation of host inflammatory response, which suggests an important role of Nsp2 in pathogenesis and disease outcomes." @default.
• W2092484297 created "2016-06-24" @default.
• W2092484297 creator A5019466916 @default.
• W2092484297 creator A5030556972 @default.
• W2092484297 creator A5052030148 @default.
• W2092484297 creator A5053496877 @default.
• W2092484297 creator A5054220107 @default.
• W2092484297 creator A5058380236 @default.
• W2092484297 creator A5066099820 @default.
• W2092484297 creator A5074707535 @default.
• W2092484297 date "2012-04-30" @default.
• W2092484297 modified "2023-10-01" @default.
• W2092484297 title "Porcine reproductive and respiratory syndrome virus nonstructural protein 2 contributes to NF-κB activation" @default.
• W2092484297 cites W1541450398 @default.
• W2092484297 cites W1686857001 @default.
• W2092484297 cites W1966375782 @default.
• W2092484297 cites W1968038394 @default.
• W2092484297 cites W1970772005 @default.
• W2092484297 cites W1975332166 @default.
• W2092484297 cites W1987382705 @default.
• W2092484297 cites W1995184275 @default.
• W2092484297 cites W2000627721 @default.
• W2092484297 cites W2003326274 @default.
• W2092484297 cites W2010562722 @default.
• W2092484297 cites W2021008297 @default.
• W2092484297 cites W2029598269 @default.
• W2092484297 cites W2029633620 @default.
• W2092484297 cites W2036627785 @default.
• W2092484297 cites W2040654802 @default.
• W2092484297 cites W2066868766 @default.
• W2092484297 cites W2067489401 @default.
• W2092484297 cites W2069531923 @default.
• W2092484297 cites W2083890425 @default.
• W2092484297 cites W2089186775 @default.
• W2092484297 cites W2103854602 @default.
• W2092484297 cites W2105926865 @default.
• W2092484297 cites W2106877484 @default.
• W2092484297 cites W2107513655 @default.
• W2092484297 cites W2115709212 @default.
• W2092484297 cites W2117365587 @default.
• W2092484297 cites W2123460889 @default.
• W2092484297 cites W2128738205 @default.
• W2092484297 cites W2129620275 @default.
• W2092484297 cites W2130591918 @default.
• W2092484297 cites W2133074755 @default.
• W2092484297 cites W2133784511 @default.
• W2092484297 cites W2137941909 @default.
• W2092484297 cites W2141475236 @default.
• W2092484297 cites W2144913372 @default.
• W2092484297 cites W2146200459 @default.
• W2092484297 cites W2148119611 @default.
• W2092484297 cites W2152561297 @default.
• W2092484297 cites W2156638064 @default.
• W2092484297 cites W2167073930 @default.
• W2092484297 cites W2168552645 @default.
• W2092484297 cites W2335925695 @default.
• W2092484297 cites W2999065750 @default.
• W2092484297 cites W4379365691 @default.
• W2092484297 doi "https://doi.org/10.1186/1743-422x-9-83" @default.
• W2092484297 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3443020" @default.
• W2092484297 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22546080" @default.
• W2092484297 hasPublicationYear "2012" @default.
• W2092484297 type Work @default.
• W2092484297 sameAs 2092484297 @default.
• W2092484297 citedByCount "46" @default.
• W2092484297 countsByYear W20924842972012 @default.
• W2092484297 countsByYear W20924842972013 @default.
• W2092484297 countsByYear W20924842972014 @default.
• W2092484297 countsByYear W20924842972015 @default.
• W2092484297 countsByYear W20924842972016 @default.
• W2092484297 countsByYear W20924842972017 @default.
• W2092484297 countsByYear W20924842972018 @default.
• W2092484297 countsByYear W20924842972019 @default.
• W2092484297 countsByYear W20924842972020 @default.
• W2092484297 countsByYear W20924842972021 @default.
• W2092484297 countsByYear W20924842972022 @default.
• W2092484297 countsByYear W20924842972023 @default.
• W2092484297 crossrefType "journal-article" @default.
• W2092484297 hasAuthorship W2092484297A5019466916 @default.
• W2092484297 hasAuthorship W2092484297A5030556972 @default.
• W2092484297 hasAuthorship W2092484297A5052030148 @default.
• W2092484297 hasAuthorship W2092484297A5053496877 @default.
• W2092484297 hasAuthorship W2092484297A5054220107 @default.
• W2092484297 hasAuthorship W2092484297A5058380236 @default.
• W2092484297 hasAuthorship W2092484297A5066099820 @default.
• W2092484297 hasAuthorship W2092484297A5074707535 @default.
• W2092484297 hasBestOaLocation W20924842971 @default.
• W2092484297 hasConcept C104317684 @default.
• W2092484297 hasConcept C123298856 @default.
• W2092484297 hasConcept C153911025 @default.
• W2092484297 hasConcept C159047783 @default.
• W2092484297 hasConcept C203014093 @default.
• W2092484297 hasConcept C2522874641 @default.
• W2092484297 hasConcept C2776914184 @default.
• W2092484297 hasConcept C2777730290 @default.
• W2092484297 hasConcept C2779819720 @default.
• W2092484297 hasConcept C54355233 @default.
• W2092484297 hasConcept C86339819 @default.
• W2092484297 hasConcept C86803240 @default.
• W2092484297 hasConcept C88045685 @default.

• next