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• W2092497316 abstract "IGF‐1 increased 2‐fold protein synthesis in cardiac myocytes. Genistein, whether added during preincubation or with IGF‐1 at the start of incubation, significantly inhibited the IGF‐1‐induced stimulation of protein synthesis, autophosphorylation of the β‐subunit of IGF‐1 receptor and inhibition of ERK. When added 1 or 6 h after IGF‐1, however, genistein was without effect. IGF‐1‐stimulated protein synthesis was also significantly inhibited by PD‐098059, staurosporine, and rapamycin, but not by wortmannin, in cardiac myocytes. Some inhibitors produced a reduction in cell size. Activation of the ERK cascade by IGF‐1 may be responsible for some of the features associated with cardiac myocyte hypertrophy." @default.
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• W2092497316 date "1998-01-30" @default.
• W2092497316 modified "2023-10-14" @default.
• W2092497316 title "Effect of inhibitors of signal transduction on IGF-1-induced protein synthesis associated with hypertrophy in cultured neonatal rat ventricular myocytes" @default.
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• W2092497316 doi "https://doi.org/10.1016/s0014-5793(98)00008-8" @default.
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