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• W2092499428 startingPage "25" @default.
• W2092499428 abstract "Resting and postprandial oxidative stress is elevated in those with metabolic disorders such as diabetes. Antioxidant supplementation may attenuate the rise in oxidative stress following feeding. Therefore we sought to determine the effects of acetyl L-carnitine arginate (ALCA) on resting and postprandial biomarkers of glucose and lipid metabolism, as well as oxidative stress.Twenty-nine pre-diabetic men and women were randomly assigned to either 3 g·day⁻¹ of ALCA (n = 14; 31 ± 3 yrs) or placebo (n = 15; 35 ± 3 yrs) in a double-blind design, to consume for eight weeks. Fasting blood samples were taken from subjects both pre and post intervention. After each fasting sample was obtained, subjects consumed a high fat, high carbohydrate meal and additional blood samples were taken at 1, 2, 4, and 6 hours post meal. Samples were analyzed for a variety of metabolic variables (e.g., glucose, HbA1c, lipid panel, C-reactive protein, nitrate/nitrite, and several markers of oxidative stress). Area under the curve (AUC) was calculated for each variable measured post meal, both pre and post intervention.ALCA, but not placebo, resulted in an increase in nitrate/nitrite (25.4 ± 1.9 to 30.1 ± 2.8 mumol·L⁻¹) from pre to post intervention, with post intervention values greater compared to placebo (p = 0.01). No other changes of statistical significance were noted (p > 0.05), although ALCA resulted in slight improvements in glucose (109 ± 5 to 103 ± 5 mg·dL⁻¹), HbA1c (6.6 ± 1.1 to 6.2 ± 1.2%), and HOMA-IR (3.3 ± 1.3 to 2.9 ± 1.2). AUC postprandial data were not statistically different between ALCA and placebo for any variable (p > 0.05). However, nitrate/nitrite demonstrated a moderate effect size (r = 0.35) for increase from pre (139.50 ± 18.35 mumol.L⁻¹·6 hr⁻¹) to post (172.40 ± 21.75 mumol·L⁻¹·6 hr⁻¹) intervention with ALCA, and the magnitude of decrease following feeding was not as pronounced as with placebo.Supplementation with ALCA results in an increase in resting nitrate/nitrite in pre-diabetics, without any statistically significant change in other metabolic or oxidative stress variables measured at rest or post meal." @default.
• W2092499428 created "2016-06-24" @default.
• W2092499428 creator A5047779719 @default.
• W2092499428 creator A5062509091 @default.
• W2092499428 creator A5075645133 @default.
• W2092499428 date "2009-01-01" @default.
• W2092499428 modified "2023-10-05" @default.
• W2092499428 title "Effect of oral acetyl L-carnitine arginate on resting and postprandial blood biomarkers in pre-diabetics" @default.
• W2092499428 cites W116776770 @default.
• W2092499428 cites W1419922397 @default.
• W2092499428 cites W1505324034 @default.
• W2092499428 cites W1821918060 @default.
• W2092499428 cites W1863340737 @default.
• W2092499428 cites W190340854 @default.
• W2092499428 cites W1910361842 @default.
• W2092499428 cites W1930939388 @default.
• W2092499428 cites W194145145 @default.
• W2092499428 cites W1966035354 @default.
• W2092499428 cites W1969708780 @default.
• W2092499428 cites W1971323700 @default.
• W2092499428 cites W1980018066 @default.
• W2092499428 cites W1981601912 @default.
• W2092499428 cites W1987145604 @default.
• W2092499428 cites W1989280125 @default.
• W2092499428 cites W1992858960 @default.
• W2092499428 cites W1996305735 @default.
• W2092499428 cites W1998119299 @default.
• W2092499428 cites W2000656455 @default.
• W2092499428 cites W2001655408 @default.
• W2092499428 cites W2003933789 @default.
• W2092499428 cites W2004742560 @default.
• W2092499428 cites W2005646802 @default.
• W2092499428 cites W2009945730 @default.
• W2092499428 cites W2011631670 @default.
• W2092499428 cites W2013534585 @default.
• W2092499428 cites W2021479563 @default.
• W2092499428 cites W2026945332 @default.
• W2092499428 cites W2043186825 @default.
• W2092499428 cites W2046574440 @default.
• W2092499428 cites W2048005287 @default.
• W2092499428 cites W2048954823 @default.
• W2092499428 cites W2050577492 @default.
• W2092499428 cites W2050887315 @default.
• W2092499428 cites W2058550328 @default.
• W2092499428 cites W2059571578 @default.
• W2092499428 cites W2061278204 @default.
• W2092499428 cites W2064974075 @default.
• W2092499428 cites W2065119605 @default.
• W2092499428 cites W2071958960 @default.
• W2092499428 cites W2080287320 @default.
• W2092499428 cites W2087026137 @default.
• W2092499428 cites W2087882379 @default.
• W2092499428 cites W2094233006 @default.
• W2092499428 cites W2109131896 @default.
• W2092499428 cites W2113446618 @default.
• W2092499428 cites W2117696928 @default.
• W2092499428 cites W2118705731 @default.
• W2092499428 cites W2120832973 @default.
• W2092499428 cites W2121843373 @default.
• W2092499428 cites W2131142277 @default.
• W2092499428 cites W2138936938 @default.
• W2092499428 cites W2143118003 @default.
• W2092499428 cites W2146507509 @default.
• W2092499428 cites W2148637873 @default.
• W2092499428 cites W2150278099 @default.
• W2092499428 cites W2152641807 @default.
• W2092499428 cites W2156579478 @default.
• W2092499428 cites W2158362401 @default.
• W2092499428 cites W2159918504 @default.
• W2092499428 cites W2160234571 @default.
• W2092499428 cites W2165201727 @default.
• W2092499428 cites W2167952570 @default.
• W2092499428 cites W2171961310 @default.
• W2092499428 cites W2399495048 @default.
• W2092499428 cites W2464662412 @default.
• W2092499428 cites W253807129 @default.
• W2092499428 cites W2615043561 @default.
• W2092499428 cites W2785259924 @default.
• W2092499428 cites W48493471 @default.
• W2092499428 cites W49065127 @default.
• W2092499428 cites W2013583320 @default.
• W2092499428 doi "https://doi.org/10.1186/1743-7075-6-25" @default.
• W2092499428 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2697148" @default.
• W2092499428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19490608" @default.
• W2092499428 hasPublicationYear "2009" @default.
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