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- W2092503310 abstract "Inspiratory threshold loading (ITL) induces cortical activation. It is sustained over time and is resistant to distraction, suggesting automaticity. We hypothesized that ITL-induced changes in cerebral activation may differ between single-breath ITL and continuous ITL, with differences resembling those observed after cortical automatization of motor tasks. We analyzed the brain blood oxygen level dependent (BOLD) signal of 11 naive healthy volunteers during 5 min of random, single-breath ITL and 5 min of continuous ITL. Single-breath ITL increased BOLD in many areas (premotor cortices, bilateral insula, cerebellum, reticular formation of the lateral mesencephalon) and decreased BOLD in regions co-localizing with the default mode network. Continuous ITL induced signal changes in a limited number of areas (supplementary motor area). These differences are comparable to those observed before and after overlearning of motor tasks. We conclude that the respiratory-related cortical activation observed in response to ITL is likely due to automated, attention-independent mechanisms. Also, ITL activates cortical circuits right from the first breath." @default.
- W2092503310 created "2016-06-24" @default.
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- W2092503310 date "2013-12-01" @default.
- W2092503310 modified "2023-10-12" @default.
- W2092503310 title "Functional magnetic resonance imaging suggests automatization of the cortical response to inspiratory threshold loading in humans" @default.
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- W2092503310 doi "https://doi.org/10.1016/j.resp.2013.08.005" @default.
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