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• W2092503451 endingPage "943" @default.
• W2092503451 startingPage "939" @default.
• W2092503451 abstract "In order for cells to divide in a proficient manner, they must first double their biomass, which is considered to be the main rate-limiting phase of cell proliferation. Cell growth requires an abundance of energy and biosynthetic precursors such as lipids and amino acids. Consequently, the energy and nutrient status of the cell is acutely monitored and carefully maintained. mTORC1 [mammalian (or mechanistic) target of rapamycin complex 1] is often considered to be the master regulator of cell growth that enhances cellular biomass through up-regulation of protein translation. In order for cells to control cellular homoeostasis during growth, there is close signalling interplay between mTORC1 and two other protein kinases, AMPK (AMP-activated protein kinase) and ULK1 (Unc-51-like kinase 1). This kinase triad collectively senses the energy and nutrient status of the cell and appropriately dictates whether the cell will actively favour energy- and amino-acid-consuming anabolic processes such as cellular growth, or energy- and amino-acid-generating catabolic processes such as autophagy. The present review discusses important feedback mechanisms between these three homoeostatic protein kinases that orchestrate cell growth and autophagy, with a particular focus on the mTORC1 component raptor (regulatory associated protein of mammalian target of rapamycin), as well as the autophagy-initiating kinase ULK1." @default.
• W2092503451 created "2016-06-24" @default.
• W2092503451 creator A5023733296 @default.
• W2092503451 creator A5043896468 @default.
• W2092503451 date "2013-07-18" @default.
• W2092503451 modified "2023-09-27" @default.
• W2092503451 title "The kinase triad, AMPK, mTORC1 and ULK1, maintains energy and nutrient homoeostasis" @default.
• W2092503451 cites W1918384196 @default.
• W2092503451 cites W1964257510 @default.
• W2092503451 cites W1968513003 @default.
• W2092503451 cites W1969319225 @default.
• W2092503451 cites W1970637701 @default.
• W2092503451 cites W1975924645 @default.
• W2092503451 cites W1977893138 @default.
• W2092503451 cites W1978397479 @default.
• W2092503451 cites W1984537066 @default.
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• W2092503451 cites W1989540944 @default.
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• W2092503451 doi "https://doi.org/10.1042/bst20130030" @default.
• W2092503451 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23863160" @default.
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