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• W2092503820 abstract "Gossypol is a kind of yellow polyphenolic compounds extracted from root stem and seed of the cotton plant. In the present study, we investigated its immunosuppressive mechanism by using BALB/c mouse T lymphocytes in vitro. When mouse splenocytes was incubated with gossypol, the extract effectively suppress the overproduction of the cell stimulated by concanavalin A (ConA) in a dose manner. This inhibitive activity was mainly due to interfering Th1 and Th2 cytokines production and decreasing CD4+ T cell populations and ratio of CD4+/CD8+. Furthermore, we also showed that signal transduction via NF-κB, NFAT and AP-1 are critical to the ConA-induced T cell activation in mice. The data revealed that gossypol could down-regulate activation of ConA-induced NF-κB, NFAT and AP-1 signal transduction pathways in mouse T lymphocyte. These observations indicated that gossypol exhibited immunosuppressive effects by inhibition T lymphocyte activation in vitro." @default.
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• W2092503820 date "2013-08-28" @default.
• W2092503820 modified "2023-09-27" @default.
• W2092503820 title "Gossypol suppresses mouse T lymphocytes via inhibition of NFκB, NFAT and AP-1 pathways" @default.
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• W2092503820 doi "https://doi.org/10.3109/08923973.2013.830126" @default.
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