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- W2092504994 abstract "(25S)-24,24-Difluoro-1α,25,26-trihydroxyvitamin D3 (3a and its (25R)-epimer (3b), either of which is expected to be a major metabolite of 24,24-difluoro-1α,25-dihydroxyvitamin D3 (2), were synthesized. Asymmetric addition to β-ketosulfoxides (5a, 5b) of trimethylaluminum was used as a key process to construct the chiral tertiary alcohol moiety of 3a and 3b. The absolute configuration of the tertiary alcohol was determined by X-ray crystallographic analysis of 20 which is a CD-ring analog of the 3a intermediate. The configuration at the C(25) position of the metabolite was established as S by HPLC comparison between the metabolite and chemically synthesized 3a and 3b." @default.
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- W2092504994 date "1998-12-01" @default.
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- W2092504994 title "Stereoselective synthesis and structural establishment of (25S)-24,24-difluoro-1α,25,26-trihydroxyvitamin D3, a major metabolite of 24,24-difluoro-1α,25-dihydroxyvitamin D3" @default.
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- W2092504994 doi "https://doi.org/10.1016/s0040-4020(98)00949-1" @default.
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