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• W2092505220 endingPage "e39804" @default.
• W2092505220 startingPage "e39804" @default.
• W2092505220 abstract "The corpus callosum is hypothesized to play a fundamental role in integrating information and mediating complex behaviors. Here, we demonstrate that lack of normal callosal development can lead to deficits in functional connectivity that are related to impairments in specific cognitive domains. We examined resting-state functional connectivity in individuals with agenesis of the corpus callosum (AgCC) and matched controls using magnetoencephalographic imaging (MEG-I) of coherence in the alpha (8-12 Hz), beta (12-30 Hz) and gamma (30-55 Hz) bands. Global connectivity (GC) was defined as synchronization between a region and the rest of the brain. In AgCC individuals, alpha band GC was significantly reduced in the dorsolateral pre-frontal (DLPFC), posterior parietal (PPC) and parieto-occipital cortices (PO). No significant differences in GC were seen in either the beta or gamma bands. We also explored the hypothesis that, in AgCC, this regional reduction in functional connectivity is explained primarily by a specific reduction in interhemispheric connectivity. However, our data suggest that reduced connectivity in these regions is driven by faulty coupling in both inter- and intrahemispheric connectivity. We also assessed whether the degree of connectivity correlated with behavioral performance, focusing on cognitive measures known to be impaired in AgCC individuals. Neuropsychological measures of verbal processing speed were significantly correlated with resting-state functional connectivity of the left medial and superior temporal lobe in AgCC participants. Connectivity of DLPFC correlated strongly with performance on the Tower of London in the AgCC cohort. These findings indicate that the abnormal callosal development produces salient but selective (alpha band only) resting-state functional connectivity disruptions that correlate with cognitive impairment. Understanding the relationship between impoverished functional connectivity and cognition is a key step in identifying the neural mechanisms of language and executive dysfunction in common neurodevelopmental and psychiatric disorders where disruptions of callosal development are consistently identified." @default.
• W2092505220 created "2016-06-24" @default.
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• W2092505220 date "2012-08-03" @default.
• W2092505220 modified "2023-10-14" @default.
• W2092505220 title "The Role of Corpus Callosum Development in Functional Connectivity and Cognitive Processing" @default.
• W2092505220 cites W1524959298 @default.
• W2092505220 cites W1850507581 @default.
• W2092505220 cites W1965248225 @default.
• W2092505220 cites W1967111730 @default.
• W2092505220 cites W1968817642 @default.
• W2092505220 cites W1969886036 @default.
• W2092505220 cites W1970695058 @default.
• W2092505220 cites W1971407636 @default.
• W2092505220 cites W1979877610 @default.
• W2092505220 cites W1981298313 @default.
• W2092505220 cites W1984804736 @default.
• W2092505220 cites W1985567093 @default.
• W2092505220 cites W1986046233 @default.
• W2092505220 cites W1987577328 @default.
• W2092505220 cites W1988110104 @default.
• W2092505220 cites W1988618557 @default.
• W2092505220 cites W1989045420 @default.
• W2092505220 cites W1993165440 @default.
• W2092505220 cites W1994842652 @default.
• W2092505220 cites W1997695198 @default.
• W2092505220 cites W2000119474 @default.
• W2092505220 cites W2001874839 @default.
• W2092505220 cites W2002476772 @default.
• W2092505220 cites W2005605516 @default.
• W2092505220 cites W2006925741 @default.
• W2092505220 cites W2008607322 @default.
• W2092505220 cites W2009158194 @default.
• W2092505220 cites W2010641378 @default.
• W2092505220 cites W2010674281 @default.
• W2092505220 cites W2014645694 @default.
• W2092505220 cites W2019161608 @default.
• W2092505220 cites W2021016837 @default.
• W2092505220 cites W2021943010 @default.
• W2092505220 cites W2024232514 @default.
• W2092505220 cites W2030902100 @default.
• W2092505220 cites W2031322248 @default.
• W2092505220 cites W2033531594 @default.
• W2092505220 cites W2034100297 @default.
• W2092505220 cites W2035476005 @default.
• W2092505220 cites W2036146354 @default.
• W2092505220 cites W2036208196 @default.
• W2092505220 cites W2037392344 @default.
• W2092505220 cites W2038103211 @default.
• W2092505220 cites W2038760265 @default.
• W2092505220 cites W2049408535 @default.
• W2092505220 cites W2054287233 @default.
• W2092505220 cites W2056781330 @default.
• W2092505220 cites W2063220583 @default.
• W2092505220 cites W2067724039 @default.
• W2092505220 cites W2069310569 @default.
• W2092505220 cites W2072128770 @default.
• W2092505220 cites W2073561252 @default.
• W2092505220 cites W2074457840 @default.
• W2092505220 cites W2076405988 @default.
• W2092505220 cites W2076472237 @default.
• W2092505220 cites W2076824151 @default.
• W2092505220 cites W2077491345 @default.
• W2092505220 cites W2087636287 @default.
• W2092505220 cites W2090014459 @default.
• W2092505220 cites W2090943336 @default.
• W2092505220 cites W2091489592 @default.
• W2092505220 cites W2091719417 @default.
• W2092505220 cites W2092026060 @default.
• W2092505220 cites W2092416075 @default.
• W2092505220 cites W2094106149 @default.
• W2092505220 cites W2095235225 @default.
• W2092505220 cites W2095642798 @default.
• W2092505220 cites W2095768178 @default.
• W2092505220 cites W2100739993 @default.
• W2092505220 cites W2114107709 @default.
• W2092505220 cites W2116974110 @default.
• W2092505220 cites W2119252837 @default.
• W2092505220 cites W2119470559 @default.
• W2092505220 cites W2121384641 @default.
• W2092505220 cites W2124141514 @default.
• W2092505220 cites W2125531849 @default.
• W2092505220 cites W2128129825 @default.
• W2092505220 cites W2128359078 @default.
• W2092505220 cites W2132397304 @default.

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