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• W2092506817 abstract "Heart failure with preserved ejection fraction (HFpEF) accounts for about one-half of all cases of heart failure (HF) and is increasing as a proportion of all HF cases. 1 Owan T.E. Hodge D.O. Herges R.M. Jacobsen S.J. Roger V.L. Redfield M.M. Trends in prevalence and outcome of heart failure with preserved ejection fraction. New Engl J Med. 2006; 355: 251-259 Crossref PubMed Scopus (3097) Google Scholar Elevated left-sided cardiac filling pressure in the presence of normal LV volume is pathognomonic of HFpEF. 2 Borlaug B.A. Nishimura R.A. Sorajja P. Lam C.S. Redfield M.M. Exercise hemodynamics enhance diagnosis of early heart failure with preserved ejection fraction. Circ Heart Fail. 2010; 3: 588-595 Crossref PubMed Scopus (701) Google Scholar Abnormalities in active relaxation, 3 Borlaug B.A. Jaber W.A. Ommen S.R. Lam C.S. Redfield M.M. Nishimura R.A. Diastolic relaxation and compliance reserve during dynamic exercise in heart failure with preserved ejection fraction. Heart. 2011; 97: 964-969 Crossref PubMed Scopus (155) Google Scholar , 4 Wachter R. Schmidt-Schweda S. Westermann D. Post H. Edelmann F. Kasner M. et al. Blunted frequency-dependent upregulation of cardiac output is related to impaired relaxation in diastolic heart failure. Eur Heart J. 2009; 30: 3027-3036 Crossref PubMed Scopus (84) Google Scholar , 5 Phan T.T. Abozguia K. Nallur Shivu G. Mahadevan G. Ahmed I. Williams L. et al. Heart failure with preserved ejection fraction is characterized by dynamic impairment of active relaxation and contraction of the left ventricle on exercise and associated with myocardial energy deficiency. J Am Coll Cardiol. 2009; 54: 402-409 Abstract Full Text Full Text PDF PubMed Scopus (212) Google Scholar subtle impairments in systolic function despite normal ejection fraction, 6 Borlaug B.A. Lam C.S. Roger V.L. Rodeheffer R.J. Redfield M.M. Contractility and ventricular systolic stiffening in hypertensive heart disease insights into the pathogenesis of heart failure with preserved ejection fraction. J Am Coll Cardiol. 2009; 54: 410-418 Abstract Full Text Full Text PDF PubMed Scopus (322) Google Scholar dramatic deficits in systolic reserve capacity during exercise 5 Phan T.T. Abozguia K. Nallur Shivu G. Mahadevan G. Ahmed I. Williams L. et al. Heart failure with preserved ejection fraction is characterized by dynamic impairment of active relaxation and contraction of the left ventricle on exercise and associated with myocardial energy deficiency. J Am Coll Cardiol. 2009; 54: 402-409 Abstract Full Text Full Text PDF PubMed Scopus (212) Google Scholar , 7 Borlaug B.A. Olson T.P. Lam C.S. Flood K.S. Lerman A. Johnson B.D. et al. Global cardiovascular reserve dysfunction in heart failure with preserved ejection fraction. J Am Coll Cardiol. 2010; 56: 845-854 Abstract Full Text Full Text PDF PubMed Scopus (492) Google Scholar , 8 Tan Y.T. Wenzelburger F. Lee E. Heatlie G. Leyva F. Patel K. et al. The pathophysiology of heart failure with normal ejection fraction: Exercise echocardiography reveals complex abnormalities of both systolic and diastolic ventricular function involving torsion, untwist, and longitudinal motion. J Am Coll Cardiol. 2009; 54: 36-46 Abstract Full Text Full Text PDF PubMed Scopus (377) Google Scholar and β-adrenergic stimulation, 9 Norman H.S. Oujiri J. Larue S.J. Chapman C.B. Margulies K.B. Sweitzer N.K. Decreased cardiac functional reserve in heart failure with preserved systolic function. J Card Fail. 2011; 17: 301-308 Abstract Full Text Full Text PDF PubMed Scopus (44) Google Scholar as well as vascular-ventricular stiffening 10 Hundley W.G. Kitzman D.W. Morgan T.M. Hamilton C.A. Darty S.N. Stewart K.P. et al. Cardiac cycle-dependent changes in aortic area and distensibility are reduced in older patients with isolated diastolic heart failure and correlate with exercise intolerance. J Am Coll Cardiol. 2001; 38: 796-802 Abstract Full Text Full Text PDF PubMed Scopus (317) Google Scholar , 11 Kawaguchi M. Hay I. Fetics B. Kass D.A. Combined ventricular systolic and arterial stiffening in patients with heart failure and preserved ejection fraction: implications for systolic and diastolic reserve limitations. Circulation. 2003; 107: 714-720 Crossref PubMed Scopus (734) Google Scholar , 12 Schwartzenberg S. Redfield M.M. From A.M. Sorajja P. Nishimura R.A. Borlaug B.A. Effects of vasodilation in heart failure with preserved or reduced ejection fraction implications of distinct pathophysiologies on response to therapy. J Am Coll Cardiol. 2012; 59: 442-451 Abstract Full Text Full Text PDF PubMed Scopus (228) Google Scholar all contribute to the pathophysiology of HFpEF." @default.
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• W2092506817 date "2013-11-01" @default.
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• W2092506817 title "Dynamic Pulmonary Hypertension in Decompensated Heart Failure With Preserved Ejection Fraction: Is Functional Mitral Regurgitation the Driver?" @default.
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