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- W2092508504 abstract "Macroautophagy is a cellular process by which cytosolic components and organelles are degraded in double-membrane bound structures upon fusion with lysosomes. A pathway for selective degradation of mitochondria by autophagy, known as mitophagy, has been described, and is of particular importance to neurons, because of the constant need for high levels of energy production in this cell type. Although much remains to be learned about mitophagy, it appears that the regulation of mitophagy shares key steps with the macroautophagy pathway, while exhibiting distinct regulatory steps specific for mitochondrial autophagic turnover. Mitophagy is emerging as an important pathway in neurodegenerative disease, and has been linked to the pathogenesis of Parkinson's disease through the study of recessively inherited forms of this disorder, involving PINK1 and Parkin. Recent work indicates that PINK1 and Parkin together maintain mitochondrial quality control by regulating mitophagy. In the Purkinje cell degeneration (pcd) mouse, altered mitophagy may contribute to the dramatic neuron cell death observed in the cerebellum, suggesting that over-active mitophagy or insufficient mitophagy can both be deleterious. Finally, mitophagy has been linked to aging, as impaired macroautophagy over time promotes mitochondrial dysfunction associated with the aging process. Understanding the role of mitophagy in neural function, neurodegenerative disease, and aging represents an essential goal for future research in the autophagy field. This article is part of a Special Issue entitled Autophagy and protein degradation in neurological diseases." @default.
- W2092508504 created "2016-06-24" @default.
- W2092508504 creator A5036289751 @default.
- W2092508504 creator A5064140449 @default.
- W2092508504 date "2011-07-01" @default.
- W2092508504 modified "2023-10-08" @default.
- W2092508504 title "Mitochondrial autophagy in neural function, neurodegenerative disease, neuron cell death, and aging" @default.
- W2092508504 cites W1495683398 @default.
- W2092508504 cites W1503983308 @default.
- W2092508504 cites W1539974059 @default.
- W2092508504 cites W1877873625 @default.
- W2092508504 cites W1919353 @default.
- W2092508504 cites W1940885739 @default.
- W2092508504 cites W1965827991 @default.
- W2092508504 cites W1968843321 @default.
- W2092508504 cites W1969201332 @default.
- W2092508504 cites W1969342645 @default.
- W2092508504 cites W1969971911 @default.
- W2092508504 cites W1970436894 @default.
- W2092508504 cites W1972771185 @default.
- W2092508504 cites W1976195583 @default.
- W2092508504 cites W1978268445 @default.
- W2092508504 cites W1985119207 @default.
- W2092508504 cites W1986216002 @default.
- W2092508504 cites W1990069067 @default.
- W2092508504 cites W1990287702 @default.
- W2092508504 cites W1993479669 @default.
- W2092508504 cites W1993755934 @default.
- W2092508504 cites W1999893655 @default.
- W2092508504 cites W2002239634 @default.
- W2092508504 cites W2005764967 @default.
- W2092508504 cites W2006379278 @default.
- W2092508504 cites W2006909664 @default.
- W2092508504 cites W2009284075 @default.
- W2092508504 cites W2012040176 @default.
- W2092508504 cites W2014918593 @default.
- W2092508504 cites W2015905687 @default.
- W2092508504 cites W2017028262 @default.
- W2092508504 cites W2017689311 @default.
- W2092508504 cites W2022812113 @default.
- W2092508504 cites W2022852477 @default.
- W2092508504 cites W2023338943 @default.
- W2092508504 cites W2024595059 @default.
- W2092508504 cites W2025364264 @default.
- W2092508504 cites W2027566683 @default.
- W2092508504 cites W2028695079 @default.
- W2092508504 cites W2034087770 @default.
- W2092508504 cites W2035550923 @default.
- W2092508504 cites W2037640340 @default.
- W2092508504 cites W2041255615 @default.
- W2092508504 cites W2046351190 @default.
- W2092508504 cites W2047242847 @default.
- W2092508504 cites W2050849483 @default.
- W2092508504 cites W2050904202 @default.
- W2092508504 cites W2051964908 @default.
- W2092508504 cites W2052135847 @default.
- W2092508504 cites W2054583993 @default.
- W2092508504 cites W2057147625 @default.
- W2092508504 cites W2058077965 @default.
- W2092508504 cites W2058653820 @default.
- W2092508504 cites W2065060908 @default.
- W2092508504 cites W2065582101 @default.
- W2092508504 cites W2066727453 @default.
- W2092508504 cites W2066800765 @default.
- W2092508504 cites W2067474322 @default.
- W2092508504 cites W2068288454 @default.
- W2092508504 cites W2073342372 @default.
- W2092508504 cites W2074833985 @default.
- W2092508504 cites W2080746576 @default.
- W2092508504 cites W2080864745 @default.
- W2092508504 cites W2087360216 @default.
- W2092508504 cites W2087630325 @default.
- W2092508504 cites W2091852463 @default.
- W2092508504 cites W2092310066 @default.
- W2092508504 cites W2094162211 @default.
- W2092508504 cites W2099146007 @default.
- W2092508504 cites W2104382960 @default.
- W2092508504 cites W2105754268 @default.
- W2092508504 cites W2106444069 @default.
- W2092508504 cites W2107257651 @default.
- W2092508504 cites W2108326484 @default.
- W2092508504 cites W2109034822 @default.
- W2092508504 cites W2111567059 @default.
- W2092508504 cites W2115742671 @default.
- W2092508504 cites W2119301557 @default.
- W2092508504 cites W2120640283 @default.
- W2092508504 cites W2121760835 @default.
- W2092508504 cites W2128101513 @default.
- W2092508504 cites W2128537698 @default.
- W2092508504 cites W2129447571 @default.
- W2092508504 cites W2129687643 @default.
- W2092508504 cites W2130458413 @default.
- W2092508504 cites W2135732941 @default.
- W2092508504 cites W2136388422 @default.
- W2092508504 cites W2138311396 @default.
- W2092508504 cites W2139425230 @default.
- W2092508504 cites W2139636031 @default.
- W2092508504 cites W2139826556 @default.